The hereditary spastic paraplegias (HSPs) are a group of genetic conditions in which spastic paralysis of the legs is the principal clinical feature. This is caused by a relatively selective distal axonal degeneration involving the longest axons of the corticospinal tracts. Consequently, these conditions provide an opportunity to identify genes, proteins and cellular pathways that are critical for axonal health. In this review, we will provide a brief overview of the classification, clinical features and genetics of HSP, highlighting selected HSP subtypes (i.e. those associated with thin corpus callosum or cerebellar ataxia) that are of particular clinical interest. We will then discuss appropriate investigation strategies for HSPs, suggest...
Doctoral thesis Anna Uhrová Mészárosová, MSc. The Application of Massively Parallel Next Generation ...
The term Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodeg...
Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurologi...
Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders characterized by ...
Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative dis...
Introduction: The hereditary spastic paraplegias (HSPs), a heterogeneous group of inherited disorder...
International audienceHereditary spastic paraplegias (HSPs) are a group of rare, inherited, neurolog...
International audienceHereditary spastic paraplegias (HSPs) are heterogeneous neurodegenerative diso...
Hereditary spastic paraplegias (HSPs) are a group of single-gene disorders characterised by degenera...
International audienceHereditary spastic paraplegias (HSP) are a heterogeneous group of motor neurod...
Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative dis...
Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders characterized by ...
Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodegenerative...
peer reviewedMolecular characterization is important for an accurate diagnosis in hereditary spastic...
The Hereditary Spastic Paraplegias (HSP) comprise a group of neurodegenerative diseases characterize...
Doctoral thesis Anna Uhrová Mészárosová, MSc. The Application of Massively Parallel Next Generation ...
The term Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodeg...
Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurologi...
Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders characterized by ...
Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative dis...
Introduction: The hereditary spastic paraplegias (HSPs), a heterogeneous group of inherited disorder...
International audienceHereditary spastic paraplegias (HSPs) are a group of rare, inherited, neurolog...
International audienceHereditary spastic paraplegias (HSPs) are heterogeneous neurodegenerative diso...
Hereditary spastic paraplegias (HSPs) are a group of single-gene disorders characterised by degenera...
International audienceHereditary spastic paraplegias (HSP) are a heterogeneous group of motor neurod...
Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative dis...
Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders characterized by ...
Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodegenerative...
peer reviewedMolecular characterization is important for an accurate diagnosis in hereditary spastic...
The Hereditary Spastic Paraplegias (HSP) comprise a group of neurodegenerative diseases characterize...
Doctoral thesis Anna Uhrová Mészárosová, MSc. The Application of Massively Parallel Next Generation ...
The term Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodeg...
Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurologi...