The melanocortin-1 receptor (MC1R) is a key regulator of mammalian pigmentation. Melanism in the grey squirrel is associated with an eight amino acid deletion in the mutant melanocortin-1 receptor with 24 base pair deletion (MC1RΔ24) variant. We demonstrate that the MC1RΔ24 exhibits a higher basal activity than the wildtype MC1R (MC1R-wt). We demonstrate that agouti signalling protein (ASIP) is an inverse agonist to the MC1R-wt but is an agonist to the MC1RΔ24. We conclude that the deletion in the MC1RΔ24 leads to a receptor with a high basal activity which is further activated by ASIP. This is the first report of ASIP acting as an agonist to MC1R
The melanocortin receptor, MC1R, is a key regulator of pigmentation in mammals, and is necessary for...
In mice and humans, binding of α-melanocyte–stimulating hormone to the melanocyte-stimulating–hormon...
In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated...
AbstractThe melanocortin-1 receptor (MC1R) is a key regulator of mammalian pigmentation. Melanism in...
Sequence variations in the melanocortin 1 receptor (MC1R) gene are associated with melanism in many ...
The grey squirrel (Sciurus carolinensis) has wildtype and melanic (dark) colour morphs. Melanism is...
The black squirrel is a melanic variant of the gray squirrel (Sciurus carolinensis). We found 3 coat...
The black squirrel is a melanic variant of the gray squirrel (Sciurus carolinensis). We found 3 coat...
Sequence variations in the melanocortin 1 receptor (MC1R) gene are associated with melanism in many ...
During the past few years, the population of melanistic squirrels in Nebraska has increased. These c...
Variation in skin color is the major host risk factor for melanoma and other forms of skin cancer. I...
The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a s...
Background: While our understanding of the genetic basis of convergent evolution has improved there ...
8 pages, 4 figuresThe melanocortin system is a complex neuroendocrine signaling mechanism involved i...
In vertebrates, melanin-based coloration is often associated with variation in physiological and beh...
The melanocortin receptor, MC1R, is a key regulator of pigmentation in mammals, and is necessary for...
In mice and humans, binding of α-melanocyte–stimulating hormone to the melanocyte-stimulating–hormon...
In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated...
AbstractThe melanocortin-1 receptor (MC1R) is a key regulator of mammalian pigmentation. Melanism in...
Sequence variations in the melanocortin 1 receptor (MC1R) gene are associated with melanism in many ...
The grey squirrel (Sciurus carolinensis) has wildtype and melanic (dark) colour morphs. Melanism is...
The black squirrel is a melanic variant of the gray squirrel (Sciurus carolinensis). We found 3 coat...
The black squirrel is a melanic variant of the gray squirrel (Sciurus carolinensis). We found 3 coat...
Sequence variations in the melanocortin 1 receptor (MC1R) gene are associated with melanism in many ...
During the past few years, the population of melanistic squirrels in Nebraska has increased. These c...
Variation in skin color is the major host risk factor for melanoma and other forms of skin cancer. I...
The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a s...
Background: While our understanding of the genetic basis of convergent evolution has improved there ...
8 pages, 4 figuresThe melanocortin system is a complex neuroendocrine signaling mechanism involved i...
In vertebrates, melanin-based coloration is often associated with variation in physiological and beh...
The melanocortin receptor, MC1R, is a key regulator of pigmentation in mammals, and is necessary for...
In mice and humans, binding of α-melanocyte–stimulating hormone to the melanocyte-stimulating–hormon...
In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated...