Analysis of risk factors in 3901 patients with stroke

OBJECTIVE: To estimate the frequency of various risk factors for overall stroke and to identify risk factors for cerebral infarction (CI) versus intracerebral hemorrhage (ICH) in a large hospital-based stroke registry. METHOD: Data from a total of 3901 patients, consisting of 3525 patients with CI and 376 patients with ICH were prospectively coded and entered into a computerized data bank. RESULTS: Hypertension and smoking were the most prominent factors affecting overall stroke followed by mild internal carotid artery stenosis (&lt; 50%), hypercholesterolemia, transient ischemic attacks (TIAs), diabetes mellitus, and cardiac ischemia. Univariate analysis showed that factors in male significantly associated with CI versus ICH were old age, a family history of stroke, and intermittent claudication; whereas in female the factors were oral contraception and migraine. By multivariate analysis, in all patients, the factors significantly associated with CI as opposed to ICH were smoking, hypercholesterolemia, migraine, TIAs, atrial fibrillation, structural heart disease, and arterial disease. Hypertension was the only significant factor related with ICH versus CI. CONCLUSIONS: The factors for ischemic and hemorrhagic stroke are not exactly the same. Cardiac and arterial disease are the most powerful factors associated with CI rather than ICH. [Authors]]]> Cerebral Hemorrhage ; Cerebral Infarction ; Cerebrovascular Accident oai:serval.unil.ch:BIB_008233EDDE06 2022-05-07T01:08:59Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_008233EDDE06 Integration of frameless digitally subtraction angiography using vessel tree segmentation for stereotactic targeting of arterio-venous malformation Gevaert, T. Steenbecke, F. Tuleasca, C. Engels, B. Levivier, M. De Ridder, M. info:eu-repo/semantics/conferenceObject inproceedings 2014 AVM 2014, 2nd World AVM Congress eng oai:serval.unil.ch:BIB_008263BC9CAB 2022-05-07T01:08:59Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_008263BC9CAB Chemostratigraphy (δ&lt;sup&gt;13&lt;/sup&gt;C&lt;inf&gt;org&lt;/inf&gt;, δ&lt;sup&gt;13&lt;/sup&gt;C&lt;inf&gt;inorg&lt;/inf&gt;, δ&lt;sup&gt;18&lt;/sup&gt;O&lt;inf&gt;PO4&lt;/inf&gt;) of the phosphate series from the Ouled Abdoun Basin, Morocco: Constraints and significance for earliest known African placental mammals info:doi:10.3301/ROL.2014.136 info:eu-repo/semantics/altIdentifier/doi/10.3301/ROL.2014.136 http://www.scopus.com/inward/record.url?eid=2-s2.0-84984685546&amp;partnerID=MN8TOARS Yans, J. Kocsis, L. Gheerbrant, E. Amaghzaz, M. Bouya, B. Cappetta, H. Iacumin, P. Mouflih, M. Selloum, O. Sen, S. Noiret, C. Storm, J.-Y. info:eu-repo/semantics/article article 2014 Rendiconti Online Societa Geologica Italiana, vol. 31, pp. 230-231 eng oai:serval.unil.ch:BIB_0082CCE30206 2022-05-07T01:08:59Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_0082CCE30206 Impact of genetic SLC28 transporter and ITPA variants on ribavirin 21 serum level, hemoglobin drop and therapeutic response in patients with HCV infection http://www.smw.ch/fileadmin/smw/pdf/Supplementa_2012/SMW_Suppl-194.pdf Rau, M. Stickel, F. Russmann, S. Weisskopf, M. Schmitt, J. Dill, M.T. Dufour, J.F. Moradpour, D. Semela, D. Müllhaupt, B. Geier, A. info:eu-repo/semantics/conferenceObject inproceedings 2012 Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society of Visceral Surgery, Swiss Association of the Study of the Liver and Swiss Society of Clinical Nutrition, vol. 142, pp. S7 info:eu-repo/semantics/altIdentifier/isbn/1424-7860 urn:issn:0036-7672 <![CDATA[Background: T reatment o f chronic hepatitis C i s evolving, a nd direct acting antivirals ( DAAs) are now a dded to p egylated interferon-α ( Peg- INF-α) and ribavirin (RBV) for the treatment o f hepatitis C v irus ( HCV) genotype 1 infection. DAAs c ause d ifferent side effects and can even worsen RBV induced hemolytic anemia. T herefore, identifying host genetic d eterminants of R BV bioavailability and therapeutic e fficacy will remain crucial for individualized treatment. Recent d ata showed associations between R BV induced h emolytic anemia and genetic polymorphisms o f concentrative nucleoside transporters s uch as C NT3 (SLC28A3) and i nosine t riphosphatase (ITPA). T o analyze t he association of genetic variants of SLC28 transporters and ITPA with RBV induced hemolytic anemia and treatment o utcome. Methods: I n our study, 173 patients f rom t he S wiss Hepatitis C C ohort Study and 2 2 patients from Swiss Association for the Study of the Liver study 24 (61% HCV g enotype 1, 3 9% genotypes 2 o r 3) were analyzed for SLC28A2 single nucleotide p olymorphism (SNP) rs11854484, SLC28A3 rs56350726 and SLC28A3 rs10868138 as well as ITPA SNPs rs1127354 and rs7270101. RBV serum levels during treatment were measured in 49 patients. Results: SLC28A2 r s11854484 genotype TT was associated with significantly higher dosage- and body weight-adjusted RBV levels as compared to genotypes TC and CC (p=0.04 and p=0.02 at weeks 4 and 8, respectively). ITPA SNPs rs1127354 and rs7270101 were associated with h emolytic a nemia both in genotype as w ell as i n allelic a nalyses. SLC28A3 rs56350726 genotype TT (vs. AT/AA, RR=2.1; 95% CI 1.1-4.1) as well as the T allele (vs. A; RR=1.8, 95% CI 1.1-3.2) were associated with increased SVR rates. The combined analysis of overall ITPA activity and SLC28 v ariants together revealed n o significant a dditive effects on either treatment-related anemia or SVR. Conclusions: T he newly identified association between RBV serum levels a nd SLC28A2 rs11854484 genotype as well as the replicated association of ITPA and SLC28A3 g enetic p olymorphisms w ith RBV induced hemolytic anemia and treatment r esponse underpin the need for further studies on host genetic d eterminants of R BV bioavailability and therapeutic e fficacy f or individualized treatment of chronic hepatitis C