Formation postgraduée et continue des médecins à la désaccoutumance au tabac : description d'un programme efficace [Training physicians in smoking cessation: research and education serving public health]

Le tabagisme est un problème majeur de santé publique ; l'arrêt du tabac est bénéfique mais difficile car c'est à la fois un processus par étapes à travers différents stades de motivation croissante et une désaccoutumance à la nicotine, dont la plupart des fumeurs sont dépendants. Le médecin est idéalement placé pour aider efficacement les fumeurs à cesser de fumer grâce à des conseils adaptés à la motivation et aux traitements pharmacologiques. Un groupe suisse a développé un programme de formation des médecins à la désaccoutumance au tabac basé sur le «modèle transthéorique du changement» et des méthodes interactives, axées sur la pratique. Une étude randomisée a démontré que ce programme est efficace pour améliorer les pratiques des médecins et le taux d'abstinence des patients fumeurs. Un programme national diffuse actuellement cet enseignement par l'intermédiaire de médecins multiplicateurs chargés de former leurs collègues dans leur réseau professionnel. [Auteurs]]]> Smoking Cessation; Smoking; Education, Medical, Continuing fre oai:serval.unil.ch:BIB_0595073FACA4 2023-07-29T01:15:51Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_0595073FACA4 How to Avoid Black Markets for Appointments with Online Booking Systems info:doi:10.1257/aer.20191204 info:eu-repo/semantics/altIdentifier/doi/10.1257/aer.20191204 Hakimov, Rustamdjan Heller, C.-Philipp Kübler, Dorothea Kurino, Morimitsu info:eu-repo/semantics/article article 2021-07-01 American Economic Review, vol. 111, no. 7, pp. 2127-2151 info:eu-repo/semantics/altIdentifier/pissn/0002-8282 Economics and Econometrics eng oai:serval.unil.ch:BIB_05953B9DEB87 2023-07-29T01:15:51Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_05953B9DEB87 Role of the Na,K-ATPase beta-subunit in the cellular accumulation and maturation of the enzyme as assessed by glycosylation inhibitors info:doi:10.1007/BF01871903 info:eu-repo/semantics/altIdentifier/doi/10.1007/BF01871903 info:eu-repo/semantics/altIdentifier/pmid/2846851 Zamofing, D. Rossier, B. C. Geering, K. info:eu-repo/semantics/article article 1988-08 Journal of Membrane Biology, vol. 104, no. 1, pp. 69-79 info:eu-repo/semantics/altIdentifier/pissn/0022-2631 <![CDATA[No functional role could yet be established for the glycosylated beta-subunit of the Na,K-ATPase. In this study, we describe the intracellular processing of the beta-subunit as a glycoprotein in toad bladder cells and the consequences of its structural perturbation with glycosylation inhibitors on the cellular expression of the alpha- and beta-subunits and on the structural and functional maturation of the enzyme. Controlled trypsinolysis of homogenates from pulse-labeled cells reveals that the beta-subunit is subjected to glycosylation-dependent structural rearrangements during its intracellular routing. Inhibition of correct terminal glycosylation of the beta-subunit with deoxynojirimycin or swainsonine has no effect on the trypsin sensitivity of the alpha-subunit, its ability to perform cation-dependent conformation changes or the cellular Na,K-ATPase activity. Acquisition of core-sugars is sufficient for the enzyme to assume its catalytic functions. On the other hand, complete inhibition of glycosylation with tunicamycin leads to a destabilization of both the beta- and the alpha-subunits as judged by their higher trypsin sensitivity. In addition, tunicamycin treatment results in a decrease of the amount of newly synthesized beta- and alpha-subunit indicating that a glycoprotein, possibly the beta-subunit itself, plays a role in the efficient accumulation of the alpha-subunit in the endoplasmic reticulum