Economic implications of nonadherence to highly active antiretroviral treatment in HIV patients

Until now, the economic implications of nonadherence to drug therapies have been mostly assessed in a cost perspective and understood as the impact of nonadherence behaviours on the cost-effectiveness ratios of particular therapies. In HIV disease, some modelling approaches have suggested that high adherence levels might improve the cost-effectiveness of highly active antiretroviral treatment regimens. However, there is an urgent need for research directly observing and measuring the costs of nonadherence behaviours. In addition to this cost perspective, the authors argue that the economic impact of nonadherence should also be studied in a microeconomic--patient-oriented--perspective. Major implications of this microeconomic perspective are drawn. First, the microeconomic approach highlights that nonadherence may often be a rational choice of the patient, thus suggesting new ways for improving adherence. Second, it implies that the adherence behaviour can be interpreted as an indicator of patients' subjective valuation of highly active antiretroviral treatment therapies; in particular, higher levels of adherence are associated with higher patient well-being. Third, it shows that the adherence behaviour cannot be regarded as an exogenous variable when the impact of adherence on health outcome or on cost-effectiveness ratios is studied, thus requiring the use of specific statistical or econometric methods. [Authors]]]> Z3, Antiretroviral Therapy, Highly Active ; HIV Infections ; HIV-1 ; Patient Compliance eng oai:serval.unil.ch:BIB_34C46AB37C8F 2023-07-29T01:21:43Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_34C46AB37C8F La caricature dans le canton de Vaud : dialogues graphique et politique Kaenel, P. info:eu-repo/semantics/conferenceObject inproceedings 2009 Art et politique dans le canton de Vaud au XIXe siècle : une relation équivoque, pp. 203-216 Meuwly, O. (ed.) info:eu-repo/semantics/altIdentifier/isbn/9782940066070 fre oai:serval.unil.ch:BIB_34C491925732 2023-07-29T01:21:43Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_34C491925732 Abnormal stock returns using supply chain momentum and operational financials info:doi:10.3905/jpm.2017.43.2.050 info:eu-repo/semantics/altIdentifier/doi/10.3905/jpm.2017.43.2.050 Paatela, A. Noschis, E. Hameri, A.-P. info:eu-repo/semantics/article article 2017 The Journal of Portfolio Management, vol. 43, no. 2, pp. 50-60 info:eu-repo/semantics/altIdentifier/pissn/0095-4918 <![CDATA[Knowledge about a company's supply chain provides an edge for investors. In this new proposed trading approach, a company's stock is only purchased if its main customer's quarterly sales evolve favourably. This method yields backtested annual returns in excess of 8.7% to the market return net of real world transaction costs for a stock portfolio built on supply chain considerations. This portfolio is practically uncorrelated with the market and the abnormal return is robust for risk-adjustment. The method is applicable at least for U.S. listed small and mid-cap product manufacturing companies with a strong dependency on their main customer company. Our review of past publications could not identify research applying a similar method, thereby confirming the novelty of this fundamental facts based approach