Adipose tissue is a regulated source of interleukin-10

Juge-Aubry, C. E.
Somm, E.
Pernin, A.
Alizadeh, N.
Giusti, V.
Dayer, J. M.
Meier, C. A.

Open link

Publication date

March 2005

DOI

10.1016/j.cyto.2004.10.017

Publisher

Elsevier BV

ISSN

1043-4666

Citation count (estimate)

Abstract

White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase)