High-dose TNF-alpha plus chemotherapy, with or without IFN-gamma, can be safely administered regionally through isolated limb perfusion. This procedure produced between 70% and 80% complete remission in cases of in transit melanoma metastases and between 25% and 36% complete remission in cases of inextirpable soft-tissue sarcomas. Dual targeting is involved; TNF-alpha and IFN-gamma induce apoptosis of angiogenic endothelium, while melphalan induces apoptosis of tumour cells
Tumor necrosis factor (TNF)-alpha was originally identified in the 1970s as the serum mediator of in...
Tumor necrosis factor alpha (TNF-alpha), isolated 30 years ago, is a multifunctional cytokine playin...
textabstractDuring isolated limb perfusion with TNFα and melphalan, patients are exposed to high co...
High-dose TNF-alpha plus chemotherapy, with or without IFN-gamma, can be safely administered regiona...
The authors review their experience of 4 years with isolated limb perfusion for the application of h...
Recombinant human TNF (rhTNF) has a selective effect on endothelial cells in tumour angiogenic vesse...
The unique property of high dose recombinant tumor necrosis factor alpha (rTNF alpha) is to activate...
Recombinant tumor necrosis factor-alpha (rTNF alpha) has potent antitumor activity in experimental s...
Recombinant human tumour necrosis factor (TNF) has a selective effect on angiogenic vessels in tumou...
Isolated perfusion of the limbs (ILP) allows the delivery of high dose rTNF alpha in a closed system...
This open, multicentre, randomized phase II trial was conducted to determine the effect of isolated ...
Recombinant tumour necrosis factor-alpha (rTNFalpha) possesses the unique property of activating and...
Background: In isolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNF alpha) and interf...
Item does not contain fulltextLimb-sparing surgery has become all the more important in soft tissue ...
Tumor necrosis factor (TNF)-alpha was originally identified in the 1970s as the serum mediator of in...
Tumor necrosis factor alpha (TNF-alpha), isolated 30 years ago, is a multifunctional cytokine playin...
textabstractDuring isolated limb perfusion with TNFα and melphalan, patients are exposed to high co...
High-dose TNF-alpha plus chemotherapy, with or without IFN-gamma, can be safely administered regiona...
The authors review their experience of 4 years with isolated limb perfusion for the application of h...
Recombinant human TNF (rhTNF) has a selective effect on endothelial cells in tumour angiogenic vesse...
The unique property of high dose recombinant tumor necrosis factor alpha (rTNF alpha) is to activate...
Recombinant tumor necrosis factor-alpha (rTNF alpha) has potent antitumor activity in experimental s...
Recombinant human tumour necrosis factor (TNF) has a selective effect on angiogenic vessels in tumou...
Isolated perfusion of the limbs (ILP) allows the delivery of high dose rTNF alpha in a closed system...
This open, multicentre, randomized phase II trial was conducted to determine the effect of isolated ...
Recombinant tumour necrosis factor-alpha (rTNFalpha) possesses the unique property of activating and...
Background: In isolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNF alpha) and interf...
Item does not contain fulltextLimb-sparing surgery has become all the more important in soft tissue ...
Tumor necrosis factor (TNF)-alpha was originally identified in the 1970s as the serum mediator of in...
Tumor necrosis factor alpha (TNF-alpha), isolated 30 years ago, is a multifunctional cytokine playin...
textabstractDuring isolated limb perfusion with TNFα and melphalan, patients are exposed to high co...
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