The manner by which genotype and environment affect complex phenotypes is one of the fundamental questions in biology. In this study, we quantified the transcriptome--a subset of the metabolome--and, using targeted proteomics, quantified a subset of the liver proteome from 40 strains of the BXD mouse genetic reference population on two diverse diets. We discovered dozens of transcript, protein, and metabolite QTLs, several of which linked to metabolic phenotypes. Most prominently, Dhtkd1 was identified as a primary regulator of 2-aminoadipate, explaining variance in fasted glucose and diabetes status in both mice and humans. These integrated molecular profiles also allowed further characterization of complex pathways, particularly the mitoc...
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significant...
We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from ge...
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to...
The manner by which genotype and environment affect complex phenotypes is one of the fundamental que...
peer reviewedThe manner by which genotype and environment affect complex phenotypes is one of the fu...
SummaryThe manner by which genotype and environment affect complex phenotypes is one of the fundamen...
The manner by which genotype and environment affect complex phenotypes is one of the fundamental que...
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significant...
Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition o...
peer reviewedPhenome-wide association is a novel reverse genetic strategy to analyze genome-to-pheno...
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to...
Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition o...
peer reviewedWe have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes coll...
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to...
With the completion of the many genomes, genetics is positioned to meet physiology. In this review, ...
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significant...
We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from ge...
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to...
The manner by which genotype and environment affect complex phenotypes is one of the fundamental que...
peer reviewedThe manner by which genotype and environment affect complex phenotypes is one of the fu...
SummaryThe manner by which genotype and environment affect complex phenotypes is one of the fundamen...
The manner by which genotype and environment affect complex phenotypes is one of the fundamental que...
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significant...
Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition o...
peer reviewedPhenome-wide association is a novel reverse genetic strategy to analyze genome-to-pheno...
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to...
Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition o...
peer reviewedWe have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes coll...
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to...
With the completion of the many genomes, genetics is positioned to meet physiology. In this review, ...
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significant...
We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from ge...
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to...