La prévention du tabagisme? : une affaire à la fois individuelle et communautaire

L'année 2003 a été marquée par plusieurs nouvelles données épidémiologiques sur la consommation de tabac en Suisse, par une avancée remarquable dans le domaine de la prévention du tabagisme, et par la confirmation de l'efficacité du conseil médical. [auteur]]]> Smoking oai:serval.unil.ch:BIB_737752EF3D39 2023-07-29T01:27:38Z ehelvetica phdthesis urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_737752EF3D39 Effects of heart rate on left ventricular single beat elastance and left ventricular maximal power divided by the square of end-diastolic volume in pentobarbital anaesthetised swine Skouvaklis Danielle, Elisabeth Université de Lausanne, Faculté de médecine info:eu-repo/semantics/doctoralThesis phdthesis 2002 eng https://serval.unil.ch/resource/serval:BIB_737752EF3D39.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_737752EF3D396 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_737752EF3D396 info:eu-repo/semantics/restrictedAccess Restricted: indefinite embargo Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf X1587073074/301 <OAI-PMH xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd"> 2023-08-04T23:10:27Z http://repoint.unil.ch/oaiprovider/ oai:serval.unil.ch:BIB_7378 2023-07-29T01:27:38Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_7378 Neuro-urological and anal sphincter dysfunction. Kuntzer, T info:eu-repo/semantics/bookPart incollection 1998 Textbook of neurology, pp. 277-286 oai:serval.unil.ch:BIB_73782DADA50C 2023-07-29T01:27:38Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_73782DADA50C Ceramide enables fas to cap and kill. info:doi:10.1074/jbc.M101866200 info:eu-repo/semantics/altIdentifier/doi/10.1074/jbc.M101866200 info:eu-repo/semantics/altIdentifier/pmid/11287428 Cremesti, A. Paris, F. Grassmé, H. Holler, N. Tschopp, J. Fuks, Z. Gulbins, E. Kolesnick, R. info:eu-repo/semantics/article article 2001-06 Journal of Biological Chemistry, vol. 276, no. 26, pp. 23954-23961 info:eu-repo/semantics/altIdentifier/pissn/0021-9258 <![CDATA[Recent studies suggest that trimerization of Fas is insufficient for apoptosis induction and indicate that super-aggregation of trimerized Fas might be prerequisite. For many cell surface receptors, cross-linking by multivalent ligands or antibodies induces their lateral segregation within the plasma membrane and co-localization into "caps" on one pole of the cell. In this study, we show that capping of Fas is essential for optimal function and that capping is ceramide-dependent. In Jurkat T lymphocytes and in primary cultures of hepatocytes, ceramide elevation was detected as early as 15-30 s and peaked at 1 min after CH-11 and Jo2 anti-Fas antibody treatment, respectively. Capping was detected 30 s after Fas ligation, peaked at 2 min, and was maintained at a lower level for as long as 30 min in both cell types. Ceramide generation appeared essential for capping. Acid sphingomyelinase -/- hepatocytes were defective in Jo2-induced ceramide generation, capping, and apoptosis, and nanomolar concentrations of C(16)-ceramide restored these events. To further explore the role of ceramide in capping of Fas, we employed FLAG-tagged soluble Fas ligand (sFasL), which binds trimerized Fas but is unable to induce capping or apoptosis in Jurkat cells. Cross-linking of sFasL with M2 anti-FLAG antibody induced both events. Pretreatment of cells with natural C(16)-ceramide bypassed the necessity for forced antibody cross-linking and enabled sFasL to cap and kill. The presence of intact sphingolipid-enriched membrane domains may be essential for Fas capping since their disruption with cholesterol-depleting agents abrogated capping and prevented apoptosis. These data suggest that capping is a ceramide-dependent event required for optimal Fas signaling in some cells