Add to ORKGThe rifampin resistance of Mycobacterium leprae is due to missense mutations in the rpoB gene encoding the beta-subunit of the essential enzyme RNA polymerase. A rapid and very simple method has been developed to detect rifampin resistance in small numbers of M. leprae present in biopsies. It involves polymerase chain reaction amplification of a defined region of the rpoB gene followed by single-strand conformational polymorphism analysis (PCR-SSCP). The reliability of the method has been tested on a sample of known drug-resistant and susceptible isolates of M. leprae
Control of tuberculosis is threatened by widespread emergence of drug resistance in Mycobacterium tu...
Introduction: Conventional Mouse foot-pad (MFP) assay for screening drug resistance in M. leprae is...
PubMed ID: 12838673Rifampin is one of the most potent antituberculosis drugs and therefore, rifampin...
The rifampin resistance of Mycobacterium leprae is due to missense mutations in the rpoB gene encodi...
Drug resistance in Mycobacterium leprae is a significant problem in countries where leprosy is endem...
The control measures recommended for treatment of leprosy with multidrug therapy should limit spread...
Rifampin is a key component in the chemoterapeutic regimens used to combat both leprosy and tubercul...
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae)...
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae)...
A rapid screening test was recently established for the detection of mutations in the rpoB gene of M...
The rpoB gene encodes the β-subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae)...
Real-time PCR was used to determine rifampin resistance in clinical isolates of Mycobacterium tuberc...
The use of polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) to study...
Development and evaluation of a novel multiple-primer PCR amplification refractory mutation system f...
5 páginasOBJECTIVE: To detect the presence of rifampin- and dapsone-resistant strains of Mycobacteri...
Control of tuberculosis is threatened by widespread emergence of drug resistance in Mycobacterium tu...
Introduction: Conventional Mouse foot-pad (MFP) assay for screening drug resistance in M. leprae is...
PubMed ID: 12838673Rifampin is one of the most potent antituberculosis drugs and therefore, rifampin...
The rifampin resistance of Mycobacterium leprae is due to missense mutations in the rpoB gene encodi...
Drug resistance in Mycobacterium leprae is a significant problem in countries where leprosy is endem...
The control measures recommended for treatment of leprosy with multidrug therapy should limit spread...
Rifampin is a key component in the chemoterapeutic regimens used to combat both leprosy and tubercul...
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae)...
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae)...
A rapid screening test was recently established for the detection of mutations in the rpoB gene of M...
The rpoB gene encodes the β-subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae)...
Real-time PCR was used to determine rifampin resistance in clinical isolates of Mycobacterium tuberc...
The use of polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) to study...
Development and evaluation of a novel multiple-primer PCR amplification refractory mutation system f...
5 páginasOBJECTIVE: To detect the presence of rifampin- and dapsone-resistant strains of Mycobacteri...
Control of tuberculosis is threatened by widespread emergence of drug resistance in Mycobacterium tu...
Introduction: Conventional Mouse foot-pad (MFP) assay for screening drug resistance in M. leprae is...
PubMed ID: 12838673Rifampin is one of the most potent antituberculosis drugs and therefore, rifampin...