The receptor responsible for the transepithelial transport of IgA dimer antibodies is a transmembrane glycoprotein known as membrane secretory component (SCm). During transport, the membrane anchoring domain is cleaved and the ectoplasmic domain of the receptor (SCs) remains tightly bound to the IgA dimer in exosecretions. We have produced monoclonal antibodies with distinct specificities against both cytoplasmic and ectoplasmic epitopes of rabbit SCm. One antibody (anti-SC303) reacted both with SCm and free SCs but not with SCs bound to IgA dimer (SIgA). Therefore, it recognized an epitope close to the IgA dimer binding site. The other monoclonal antibody (anti-SC166), which was unable to react with SCs, bound to the 15-kDa cytoplasmic ext...
The transepithelial transport of polymeric immunoglobulins is an essential process in the mucosal im...
AbstractSecretory immunoglobulin (Ig) A (SIgA) is essential in protecting mucosal surfaces. It is co...
The hybridoma cell line ZAC3 expresses Vibrio cholerae lipopolysaccharide (LPS)-specific mouse IgA m...
The receptor responsible for the transepithelial transport of IgA dimer antibodies is a transmembran...
The receptor responsible for the transepithelial transport of IgA dimer antibodies is a transmembran...
The receptor that mediates the specific uptake and intracellular transport of dimeric immunoglobulin...
Recombinant secretory immunoglobulin A containing a bacterial epitope in domain I of the secretory c...
The membrane receptor of epithelial cells which binds polymeric immunoglobulins and mediates their t...
The membrane receptor of epithelial cells which binds polymeric immunoglobulins and mediates their t...
Secretory IgA dimer antibodies in exosecretions provide the primary immunological defense for mucosa...
The polymeric immunoglobulin receptor (pIgR) on mucosal epithelial cells binds dimeric IgA (dIgA) on...
Secretory component (SC), synthesized as a transmembrane protein, acts as the receptor that binds Ig...
Mucosal surfaces are protected by polymeric immunoglobulins that are transported across the epitheli...
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and c...
In intestinal secretions, secretory IgA (SIgA) plays an important sentinel and protective role in th...
The transepithelial transport of polymeric immunoglobulins is an essential process in the mucosal im...
AbstractSecretory immunoglobulin (Ig) A (SIgA) is essential in protecting mucosal surfaces. It is co...
The hybridoma cell line ZAC3 expresses Vibrio cholerae lipopolysaccharide (LPS)-specific mouse IgA m...
The receptor responsible for the transepithelial transport of IgA dimer antibodies is a transmembran...
The receptor responsible for the transepithelial transport of IgA dimer antibodies is a transmembran...
The receptor that mediates the specific uptake and intracellular transport of dimeric immunoglobulin...
Recombinant secretory immunoglobulin A containing a bacterial epitope in domain I of the secretory c...
The membrane receptor of epithelial cells which binds polymeric immunoglobulins and mediates their t...
The membrane receptor of epithelial cells which binds polymeric immunoglobulins and mediates their t...
Secretory IgA dimer antibodies in exosecretions provide the primary immunological defense for mucosa...
The polymeric immunoglobulin receptor (pIgR) on mucosal epithelial cells binds dimeric IgA (dIgA) on...
Secretory component (SC), synthesized as a transmembrane protein, acts as the receptor that binds Ig...
Mucosal surfaces are protected by polymeric immunoglobulins that are transported across the epitheli...
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and c...
In intestinal secretions, secretory IgA (SIgA) plays an important sentinel and protective role in th...
The transepithelial transport of polymeric immunoglobulins is an essential process in the mucosal im...
AbstractSecretory immunoglobulin (Ig) A (SIgA) is essential in protecting mucosal surfaces. It is co...
The hybridoma cell line ZAC3 expresses Vibrio cholerae lipopolysaccharide (LPS)-specific mouse IgA m...