A whole-genome association study of major determinants for host control of HIV-1
- Fellay, J.
- Shianna, K. V.
- Ge, D.
- Colombo, S.
- Ledergerber, B.
- Weale, M.
- Zhang, K.
- Gumbs, C.
- Castagna, A.
- Cossarizza, A.
- Cozzi-Lepri, A.
- De Luca, A.
- Easterbrook, P.
- Francioli, P.
- Mallal, S.
- Martinez-Picado, J.
- Miro, J. M.
- Obel, N.
- Smith, J. P.
- Wyniger, J.
- Descombes, P.
- Antonarakis, S. E.
- Letvin, N. L.
- McMichael, A. J.
- Haynes, B. F.
- Telenti, A.
- Goldstein, D. B.
DOIAbstract
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of stud...
Add to ORKG