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Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis

Assassi, Shervin
Swindell, William R.
Wu, Minghua
Tan, Filemon D.
Khanna, Dinesh
Furst, Daniel E.
Tashkin, Donald P.
Jahan‐tigh, Richard R.
Mayes, Maureen D.
Gudjonsson, Johann E.
Chang, Jeffrey T.

Publication date

November 2015

DOI

10.1002/art.39289

Publisher

Wiley

ISSN

2326-5191

Journal

Arthritis & Rheumatology

Language

English

Citation count (estimate)

26

Abstract

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115989/1/art39289.pd

Extracted data

Related items

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

Mahoney, J. Matthew
Taroni, Jaclyn
Martyanov, Viktor
Wood, Tammara A. A
Greene, Casey S
Pioli, Patricia A
Hinchcliff, Monique E.
Whitfield, Michael L

January 2015

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and organ fibro...

A Genomic Meta-Analysis of Clinical Variables and Their Association with Intrinsic Molecular Subsets in Systemic Sclerosis

Franks, Jennifer M
Toledo, Diana M
Martyanov, Viktor
Wang, Yue
Huang, Suiyuan
Wood, Tammara A
Spino, Cathie
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Denton, Christopher
Derrett-Smith, Emma
Gordon, Jessica K
Spiera, Robert
Domsic, Robyn
Hinchcliff, Monique
Khanna, Dinesh
Whitfield, Michael L

January 2023

OBJECTIVES: Four intrinsic molecular subsets (Inflammatory, Fibroproliferative, Limited, Normal-like...

Molecular Signatures in Skin Associated with Clinical Improvement During Mycophenolate Treatment in Systemic Sclerosis

Monique Hinchcliff
Chiang-ching Huang
Tammara A. Wood
Matthew Mahoney
Tamaki Md
John Varga
Michael L. Whitfield

August 2016

Heterogeneity in systemic sclerosis/SSc confounds clinical trials. We previously identified ‘intrins...

Skin Gene Expression Correlates of Severity of Interstitial Lung Disease in Systemic Sclerosis

Assassi, Shervin
Wu, Minghua
Tan, Filemon K.
Chang, Jeffrey
Graham, Tiffany A.
Furst, Daniel E.
Khanna, Dinesh
Charles, Julio
Ferguson, Emma C.
Feghali‐bostwick, Carol
Mayes, Maureen D.

November 2013

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100260/1/art38101.pd

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

Milano, Ausra
Pendergrass, Sarah A
Sargent, Jennifer L
George, Lacy K
McCalmont, Timothy H
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January 2008

BackgroundScleroderma is a clinically heterogeneous disease with a complex phenotype. The disease is...

Molecular subsets in the gene expression signatures of scleroderma skin

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Jennifer L. Sargent
Lacy K. George
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Correction: Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

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Sargent, Jennifer L
George, Lacy K
McCalmont, Timothy H
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Whitfield, Michael L.

July 2008

Background: Scleroderma is a clinically heterogeneous disease with a complex phenotype. The disease ...

Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature

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C.P. Denton

January 2017

Background: Systemic sclerosis (SSc; scleroderma) is an uncommon autoimmune rheumatic disease charac...

Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine

Benfaremo, Devis
Agarbati, Silvia
Mozzicafreddo, Matteo
Paolini, Chiara
Svegliati, Silvia
Moroncini, Gianluca

January 2023

Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant he...

Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology.

Kerick Martin
González-Serna David
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Teruel Maria
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Makowska Zuzanna
Buttgereit Anne
Babaei Sepideh
Barturen Guillermo
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Balog Attila
Deák Magdolna
Bocskai Márta
Dulic Sonja
Kádár Gabriella
Lesche Ralf
Beretta Lorenzo
Alarcon- Riquelme Marta E.
Martin Javier

January 2021

To identify the genetic variants that affect gene expression (expression quantitative trait loci [eQ...

Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis.

Clark, KEN
Campochiaro, C
Csomor, E
Taylor, A
Nevin, K
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Singh, J
Teo, YV
Ong, VH
Derrett-Smith, E
Wisniacki, N
Flint, SM
Denton, CP

July 2021

OBJECTIVES: Clinical heterogeneity is a cardinal feature of systemic sclerosis (SSc). Hallmark SSc a...

A Novel Multi-Network Approach Reveals Tissue-Specific Cellular Modulators of Fibrosis in Systemic Sclerosis

Taroni, Jaclyn N
Greene, Casey S
Martyanov, Viktor
Wood, Tammara A

March 2017

Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by skin fibrosis. Interna...

Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent

Experimentally-derived Fibroblast Gene
Michael E. Johnson
J. Matthewmahoney
Jaclyn Taroni
Jennifer L. Sargent
Eleni Marmarelis
John Varga
Monique E. Hinchcliff

August 2016

Genome-wide expression profiling in systemic sclerosis (SSc) has identified four ‘intrinsic’ subsets...

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

Taroni, JN
Greene, CS
Martyanov, V
Wood, TA
Christmann, RB
Farber, HW
Lafyatis, RA
Denton, CP
Hinchcliff, ME
Pioli, PA
Mahoney, JM
Whitfield, ML

March 2017

BACKGROUND: Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by skin fibro...

Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts

Johnson, Michael E
Mahoney, J. Matthew
Taroni, Jaclyn
Sargent, Jennifer L
Marmarelis, Eleni
Wu, Ming-ru
Varga, John
Hinchcliff, Monique E
Whitfield, Michael L

January 2015

Genome-wide expression profiling in systemic sclerosis (SSc) has identified four ‘intrinsic’ subsets...

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

Mahoney, J. Matthew
Taroni, Jaclyn
Martyanov, Viktor
Wood, Tammara A. A
Greene, Casey S
Pioli, Patricia A
Hinchcliff, Monique E.
Whitfield, Michael L

January 2015

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and organ fibro...

A Genomic Meta-Analysis of Clinical Variables and Their Association with Intrinsic Molecular Subsets in Systemic Sclerosis

Franks, Jennifer M
Toledo, Diana M
Martyanov, Viktor
Wang, Yue
Huang, Suiyuan
Wood, Tammara A
Spino, Cathie
Chung, Lorinda
Denton, Christopher
Derrett-Smith, Emma
Gordon, Jessica K
Spiera, Robert
Domsic, Robyn
Hinchcliff, Monique
Khanna, Dinesh
Whitfield, Michael L

January 2023

OBJECTIVES: Four intrinsic molecular subsets (Inflammatory, Fibroproliferative, Limited, Normal-like...

Molecular Signatures in Skin Associated with Clinical Improvement During Mycophenolate Treatment in Systemic Sclerosis

Monique Hinchcliff
Chiang-ching Huang
Tammara A. Wood
Matthew Mahoney
Tamaki Md
John Varga
Michael L. Whitfield

August 2016

Heterogeneity in systemic sclerosis/SSc confounds clinical trials. We previously identified ‘intrins...

Skin Gene Expression Correlates of Severity of Interstitial Lung Disease in Systemic Sclerosis

Assassi, Shervin
Wu, Minghua
Tan, Filemon K.
Chang, Jeffrey
Graham, Tiffany A.
Furst, Daniel E.
Khanna, Dinesh
Charles, Julio
Ferguson, Emma C.
Feghali‐bostwick, Carol
Mayes, Maureen D.

November 2013

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100260/1/art38101.pd

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

Milano, Ausra
Pendergrass, Sarah A
Sargent, Jennifer L
George, Lacy K
McCalmont, Timothy H
Connolly, M Kari
Whitfield, Michael L

January 2008

BackgroundScleroderma is a clinically heterogeneous disease with a complex phenotype. The disease is...

Molecular subsets in the gene expression signatures of scleroderma skin

Ausra Milano
Sarah A. Pendergrass
Jennifer L. Sargent
Lacy K. George
Timothy H. Mccalmont
M. Kari Connolly
Michael L. Whitfield

January 2008

Background: Scleroderma is a clinically heterogeneous disease with a complex phenotype. The disease ...

Correction: Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

Milano, Ausra
Pendergrass, Sarah A
Sargent, Jennifer L
George, Lacy K
McCalmont, Timothy H
Connolly, M. Kari
Whitfield, Michael L.

July 2008

Background: Scleroderma is a clinically heterogeneous disease with a complex phenotype. The disease ...

Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature

E.C. Derrett-Smith
V. Martyanov
C.B. Chighizola
P. Moinzadeh
C. Campochiaro
K. Khan
T.A. Wood
P.L. Meroni
D.J. Abraham
V.H. Ong
R. Lafyatis
M.L. Whitfield
C.P. Denton

January 2017

Background: Systemic sclerosis (SSc; scleroderma) is an uncommon autoimmune rheumatic disease charac...

Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine

Benfaremo, Devis
Agarbati, Silvia
Mozzicafreddo, Matteo
Paolini, Chiara
Svegliati, Silvia
Moroncini, Gianluca

January 2023

Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant he...

Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology.

Kerick Martin
González-Serna David
Carnero-Montoro Elena
Teruel Maria
Acosta- Herrera Marialbert
Makowska Zuzanna
Buttgereit Anne
Babaei Sepideh
Barturen Guillermo
López- Isac Elena
Kollaborációs szervezet: PRECISESADS Clinical Consortium
Kovács László
Balog Attila
Deák Magdolna
Bocskai Márta
Dulic Sonja
Kádár Gabriella
Lesche Ralf
Beretta Lorenzo
Alarcon- Riquelme Marta E.
Martin Javier

January 2021

To identify the genetic variants that affect gene expression (expression quantitative trait loci [eQ...

Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis.

Clark, KEN
Campochiaro, C
Csomor, E
Taylor, A
Nevin, K
Galwey, N
Morse, MA
Singh, J
Teo, YV
Ong, VH
Derrett-Smith, E
Wisniacki, N
Flint, SM
Denton, CP

July 2021

OBJECTIVES: Clinical heterogeneity is a cardinal feature of systemic sclerosis (SSc). Hallmark SSc a...

A Novel Multi-Network Approach Reveals Tissue-Specific Cellular Modulators of Fibrosis in Systemic Sclerosis

Taroni, Jaclyn N
Greene, Casey S
Martyanov, Viktor
Wood, Tammara A

March 2017

Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by skin fibrosis. Interna...

Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent

Experimentally-derived Fibroblast Gene
Michael E. Johnson
J. Matthewmahoney
Jaclyn Taroni
Jennifer L. Sargent
Eleni Marmarelis
John Varga
Monique E. Hinchcliff

August 2016

Genome-wide expression profiling in systemic sclerosis (SSc) has identified four ‘intrinsic’ subsets...

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

Taroni, JN
Greene, CS
Martyanov, V
Wood, TA
Christmann, RB
Farber, HW
Lafyatis, RA
Denton, CP
Hinchcliff, ME
Pioli, PA
Mahoney, JM
Whitfield, ML

March 2017

BACKGROUND: Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by skin fibro...

Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts

Johnson, Michael E
Mahoney, J. Matthew
Taroni, Jaclyn
Sargent, Jennifer L
Marmarelis, Eleni
Wu, Ming-ru
Varga, John
Hinchcliff, Monique E
Whitfield, Michael L

January 2015

Genome-wide expression profiling in systemic sclerosis (SSc) has identified four ‘intrinsic’ subsets...

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

Mahoney, J. Matthew
Taroni, Jaclyn
Martyanov, Viktor
Wood, Tammara A. A
Greene, Casey S
Pioli, Patricia A
Hinchcliff, Monique E.
Whitfield, Michael L

January 2015

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and organ fibro...

A Genomic Meta-Analysis of Clinical Variables and Their Association with Intrinsic Molecular Subsets in Systemic Sclerosis

Franks, Jennifer M
Toledo, Diana M
Martyanov, Viktor
Wang, Yue
Huang, Suiyuan
Wood, Tammara A
Spino, Cathie
Chung, Lorinda
Denton, Christopher
Derrett-Smith, Emma
Gordon, Jessica K
Spiera, Robert
Domsic, Robyn
Hinchcliff, Monique
Khanna, Dinesh
Whitfield, Michael L

January 2023

OBJECTIVES: Four intrinsic molecular subsets (Inflammatory, Fibroproliferative, Limited, Normal-like...

Molecular Signatures in Skin Associated with Clinical Improvement During Mycophenolate Treatment in Systemic Sclerosis

Monique Hinchcliff
Chiang-ching Huang
Tammara A. Wood
Matthew Mahoney
Tamaki Md
John Varga
Michael L. Whitfield

August 2016

Heterogeneity in systemic sclerosis/SSc confounds clinical trials. We previously identified ‘intrins...