In the recent literature in the philosophy of science there is much discussion of scientific knowledge, but rarely an explicit account of such knowledge. Employing the Pyrrhonist skeptics modes, I examine the implicit ‘justified true belief’ analysis of scientific knowledge presented by Stathis Psillos, the primitivist account offered by Alexander Bird, and Bas van Fraassen’s voluntarist epistemology. I conclude that all of these positions appear to fail. Psillos’ account relies on a theory of reference that cannot block skeptical challenges to scientific realism, nor can it identify natural kinds in a non-ad hoc manner. Bird’s account also cannot refute skeptical challenges to it, nor can it adequately show how the full truth necessary...