The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.
- Byakwaga, Helen
- Boum, Yap
- Huang, Yong
- Muzoora, Conrad
- Kembabazi, Annet
- Weiser, Sheri D
- Bennett, John
- Cao, Huyen
- Haberer, Jessica E
- Deeks, Steven G
- Bangsberg, David R
- McCune, Joseph M
- Martin, Jeffrey N
- Hunt, Peter W
Publication date
August 2014
DOI Publisher
Oxford University Press ISSN
0022-1899 Journal
1537-6613 Citation count (estimate)
41Abstract
Human immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and other downstream catabolites that inhibit T-cell proliferation and interleukin 17 (IL-17) production. The prognostic significance of this pathway in treated HIV disease is unknown
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