Add to ORKGIdentifying chemicals that can promote regeneration in damaged liver tissue could be critical for curing various liver diseases and accelerating the healing of liver damage. In order to study the regeneration of developing livers in zebrafish, acetaminophen was explored as a possible method for liver ablation. A chemical screening of over 250 novel compounds with unknown cellular targets and 75 compounds with stem cell targets was performed in order to identify some promising promoters of regeneration. Acetaminophen was found to successfully destroy the liver tissue of developing embryos, demonstrating its usefulness as a method of ablation in order to study regeneration. The chemical screening revealed several novel compounds and cell ...
Abstract Tissue damage induces cells into reprogramming-like cellular state, which contributes to ti...
Toxic liver injury is a leading cause of liver failure and death because of the organ’s inability to...
Drug-induced liver injury (DILI) is poorly predicted by single-cell-based assays, probably because o...
Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the Un...
Graduation date: 2011Numerous human conditions would be improved if therapies to encourage tissue re...
Metabolic activation is the primary cause of chemical toxicity including hepatotoxicity. Cytochrome ...
Acenaphthene is a polycyclic aromatic hydrocarbon (PAH) that is a widely distributed environmental p...
Graduation date: 2008The emerging field of regenerative medicine is mainly approached by two differe...
This is the publisher’s final pdf. The published article is copyrighted by the author(s) and publish...
Acute kidney injury (AKI) is a serious disorder for which there are limited clinical treatments. The...
805-810Paracetamol [acetaminophen (APAP)] toxicity is universal drug induced basis of acute hepatoto...
Conditional targeted cell ablation in zebrafish would greatly expand the utility of this genetic mod...
The zebrafish embryo (ZFE) is a promising alternative non-rodent model in toxicology, and initial st...
Abstract Acetylcholinesterase (AChE), an enzyme responsible for degradation of acetylcholine, has be...
SummaryToxic liver injury is a leading cause of liver failure and death because of the organ’s inabi...
Abstract Tissue damage induces cells into reprogramming-like cellular state, which contributes to ti...
Toxic liver injury is a leading cause of liver failure and death because of the organ’s inability to...
Drug-induced liver injury (DILI) is poorly predicted by single-cell-based assays, probably because o...
Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the Un...
Graduation date: 2011Numerous human conditions would be improved if therapies to encourage tissue re...
Metabolic activation is the primary cause of chemical toxicity including hepatotoxicity. Cytochrome ...
Acenaphthene is a polycyclic aromatic hydrocarbon (PAH) that is a widely distributed environmental p...
Graduation date: 2008The emerging field of regenerative medicine is mainly approached by two differe...
This is the publisher’s final pdf. The published article is copyrighted by the author(s) and publish...
Acute kidney injury (AKI) is a serious disorder for which there are limited clinical treatments. The...
805-810Paracetamol [acetaminophen (APAP)] toxicity is universal drug induced basis of acute hepatoto...
Conditional targeted cell ablation in zebrafish would greatly expand the utility of this genetic mod...
The zebrafish embryo (ZFE) is a promising alternative non-rodent model in toxicology, and initial st...
Abstract Acetylcholinesterase (AChE), an enzyme responsible for degradation of acetylcholine, has be...
SummaryToxic liver injury is a leading cause of liver failure and death because of the organ’s inabi...
Abstract Tissue damage induces cells into reprogramming-like cellular state, which contributes to ti...
Toxic liver injury is a leading cause of liver failure and death because of the organ’s inability to...
Drug-induced liver injury (DILI) is poorly predicted by single-cell-based assays, probably because o...