Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography
- Subramanian, Deepak R.
- Gupta, Sumit
- Burggraf, Dorothe
- Silberberg, Suzan J. vom
- Heimbeck, Irene
- Heiss-Neumann, Marion S.
- Haeussinger, Karl
- Newby, Chris
- Hargadon, Beverley
- Raj, Vimal
- Singh, Dave
- Kolsum, Umme
- Hofer, Thomas P.
- Al-Shair, Khaled
- Luetzen, Niklas
- Prasse, Antje
- Müller-Quernheim, Joachim
- Benea, Giorgio
- Leprotti, Stefano
- Boschetto, Piera
- Gorecka, Dorota
- Nowinski, Adam
- Oniszh, Karina
- Castell, Wolfgang zu
- Hagen, Michael
- Barta, Imre
- Döme, Balazs
- Strausz, Janos
- Greulich, Timm
- Vogelmeier, Claus
- Koczulla, Andreas R.
- Gut, Ivo
- Hohlfeld, Jens
- Welte, Tobias
- Lavae-Mokhtari, Mahyar
- Ziegler-Heitbrock, Loems
- Brightling, Christopher
- Parr, David G.
DOIAbstract
EvA (Emphysema versus Airway disease) is a multicentre project to study mechanisms and identify biomarkers of emphysema and airway disease in chronic obstructive pulmonary disease (COPD). The objective of this study was to delineate objectively imaging-based emphysema-dominant and airway disease-dominant phenotypes using quantitative computed tomography (QCT) indices, standardised with a novel phantom-based approach. 441 subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1-3) were assessed in terms of clinical and physiological measurements, laboratory testing and standardised QCT indices of emphysema and airway wall geometry. QCT indices were influenced by scanner non-conformity, but standardisation si...
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