Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

Total synthesis of noricumazole B establishes D-arabinose as glycan unit

Barbier, Jenny
Gerth, Klaus
Jansen, Rolf
Kirschning, Andreas

January 2012

The total synthesis of noricumazole B, a secondary metabolite from myxobacteria, was achieved. It es...

Profiling Natural Product Biosynthesis

Frankel, Brenda A
McCafferty, Dewey G

March 2004

AbstractNatural products are a rich source of therapeutics; however, artificially reengineering the ...

Neocarzinostatin chromophore: structural, mechanistic, and synthetic studies

Proteau, Philip Jerome

January 1990

Neocarzinostatin chromophore 1 is the active component of the antitumor antibiotic neocarzinostatin...

Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

Huang, Sheng
Elsayed, Somayah Sameer
Lv, Meinan
Tabudravu, Jioji
Rateb, Mostafa E.
Gyampoh, Roland
Kyeremeh, Kwaku
Ebel, Rainer
Jaspars, Marcel
Deng, Zixin
Yu, Yi
Deng, Hai

December 2015

Highlights • The biosynthetic gene cluster of neocarazostatin A was identified • A new type of car...

Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps

Huang, Sheng
Elsayed, Somayah Sameer
Lv, Meinan
Tabudravu, Jioji N.
Rateb, Mostafa E.
Gyampoh, Roland
Kyeremeh, Kwaku
Ebel, Rainer
Jaspars, Marcel
Deng, Zixin
Yu, Yi
Deng, Hai

December 2015

Neocarazostatin A (NZS) is a bacterial alkaloid with promising bioactivities against free radicals,...

Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

Liu, Yating
Su, Li
Fang, Qing
Tabudravu, Jioji
Yang, Xiaohui
Rickaby, Kirstie
Trembleau, Laurent
Kyeremeh, Kwaku
Deng, Zixin
Deng, Hai
Yu, Yi

December 2019

We thank the National Key Research and Development Program of China (2018YFA0900400), the National N...

The Neocarzinostatin Biosynthetic Gene Cluster from Streptomyces carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases

Liu, Wen
Nonaka, Koichi
Nie, Liping
Zhang, Jian
Christenson, Steven D.
Bae, Juyun
Van Lanen, Steven G.
Zazopoulos, Emmanuel
Farnet, Chris M.
Yang, Catherine F.
Shen, Ben

March 2005

SummaryThe biosynthetic gene cluster for the enediyne antitumor antibiotic neocarzinostatin (NCS) wa...

Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus

Sthapit, Basundhara
Oh, Tae-Jin
Lamichhane, Rajan
Liou, Kwangkyoung
Lee, Hei Chan
Kim, Chun-Gyu
Sohng, Jae Kyung

May 2004

AbstractEnediyne antibiotics are known for their potent antitumor activities. One such enediyne, neo...

A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

Parajuli, Anirudra
Kwak, Daniel H.
Dalponte, Luca
Leikoski, Niina
Galica, Tomas
Umeobika, Ugochukwu
Trembleau, Laurent
Bent, Andrew
Sivonen, Kaarina
Wahlsten, Matti
Wang, Hao
Rizzi, Ermano
De Bellis, Gianluca
Naismith, James
Jaspars, Marcel
Liu, Xinyu
Houssen, Wael
Fewer, David Peter

February 2017

Acknowledgements This work was supported by funding of the Academy of Finland (259505), Helsinki Uni...

Biochemical Characterization of a Cyanobactin Arginine-N-Prenylase from the Autumnalamide Biosynthetic Pathway

Clemente, Claudia
Johnson, Nicholas Ross
Ouyang, Xiaodan
Popin, Rafael V.
DallʼAngelo, Sergio
Wahlsten, Matti
Jokela, Jouni
Colombano, Alessandro
Nardone, Brunello
Fewer, David Peter
Houssen, Wael E

November 2022

Acknowledgements This project was supported by a fellowship grant from the EPSRC (no. EP/S027246/1, ...

A New and Unusual Pathway for the Reaction of Neocarzinostatin Chromophore with Thiols. Revised Structure of the Protein-Directed Thiol Adduct

Myers, Andrew G.
Arvedson, Stephen P.
Lee, Robert W.

May 1996

Neocarzinostatin (holo-NCS) is an antitumor antibiotic comprising a nonprotein chromophore component...

Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid

Fang, Qing
Wu, Linrui
Urwald, Caroline
Mugat, Morgane
Wang, Shan
Kyeremeh, Kwaku
Philips, Carol
Law, Samantha
Zhou, Yongjun
Deng, Hai

March 2021

QF and HD are grateful to the University of Aberdeen Elphinstone Scholarship and Scottish Funding Co...

Biosynthesis of the bis-prenylated alkaloids muscoride A and B

Mattila, Antti
Andsten, Rose-Marie
Jumppanen, Mikael
Assante, Michele
Jokela, Jouni
Wahlsten, Matti
Mikula, Kornelia M
Sigindere, Cihad
Kwak, Daniel H.
Gugger, Muriel
Koskela, Harri
Sivonen, Kaarina
Liu, Xinyu
Yli-Kauhaluoma, Jari
Iwaï, Hideo
Fewer, David

December 2019

Prenylation is a common step in the biosynthesis of many natural products and plays an important rol...

Genome Mining Discovery of a New Benzazepine Alkaloid Pseudofisnin A from the Marine Fungus <i>Neosartorya pseudofischeri</i> F27-1

Xiao-Xin Xue
Lin Chen
Man-Cheng Tang

October 2022

l-Kynurenine (Kyn) is an intermediate in the kynurenine pathway and is also found to be a building b...

Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase

Yang, Ming
Li, Wanlu
Zhou, Lin
Lin, Xiao
Zhang, Wenyu
Shen, Yaoyao
Deng, Hai
Lin, Hou-Wen
Zhou, Yongjun

September 2023

Funding Information: This work received financial support from the National Natural Science Foundati...

Total synthesis of noricumazole B establishes D-arabinose as glycan unit

Barbier, Jenny
Gerth, Klaus
Jansen, Rolf
Kirschning, Andreas

January 2012

The total synthesis of noricumazole B, a secondary metabolite from myxobacteria, was achieved. It es...

Profiling Natural Product Biosynthesis

Frankel, Brenda A
McCafferty, Dewey G

March 2004

AbstractNatural products are a rich source of therapeutics; however, artificially reengineering the ...

Neocarzinostatin chromophore: structural, mechanistic, and synthetic studies

Proteau, Philip Jerome

January 1990

Neocarzinostatin chromophore 1 is the active component of the antitumor antibiotic neocarzinostatin...

Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

Huang, Sheng
Elsayed, Somayah Sameer
Lv, Meinan
Tabudravu, Jioji
Rateb, Mostafa E.
Gyampoh, Roland
Kyeremeh, Kwaku
Ebel, Rainer
Jaspars, Marcel
Deng, Zixin
Yu, Yi
Deng, Hai

December 2015

Highlights • The biosynthetic gene cluster of neocarazostatin A was identified • A new type of car...

Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps

Huang, Sheng
Elsayed, Somayah Sameer
Lv, Meinan
Tabudravu, Jioji N.
Rateb, Mostafa E.
Gyampoh, Roland
Kyeremeh, Kwaku
Ebel, Rainer
Jaspars, Marcel
Deng, Zixin
Yu, Yi
Deng, Hai

December 2015

Neocarazostatin A (NZS) is a bacterial alkaloid with promising bioactivities against free radicals,...

Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

Liu, Yating
Su, Li
Fang, Qing
Tabudravu, Jioji
Yang, Xiaohui
Rickaby, Kirstie
Trembleau, Laurent
Kyeremeh, Kwaku
Deng, Zixin
Deng, Hai
Yu, Yi

December 2019

We thank the National Key Research and Development Program of China (2018YFA0900400), the National N...

The Neocarzinostatin Biosynthetic Gene Cluster from Streptomyces carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases

Liu, Wen
Nonaka, Koichi
Nie, Liping
Zhang, Jian
Christenson, Steven D.
Bae, Juyun
Van Lanen, Steven G.
Zazopoulos, Emmanuel
Farnet, Chris M.
Yang, Catherine F.
Shen, Ben

March 2005

SummaryThe biosynthetic gene cluster for the enediyne antitumor antibiotic neocarzinostatin (NCS) wa...

Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus

Sthapit, Basundhara
Oh, Tae-Jin
Lamichhane, Rajan
Liou, Kwangkyoung
Lee, Hei Chan
Kim, Chun-Gyu
Sohng, Jae Kyung

May 2004

AbstractEnediyne antibiotics are known for their potent antitumor activities. One such enediyne, neo...

A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

Parajuli, Anirudra
Kwak, Daniel H.
Dalponte, Luca
Leikoski, Niina
Galica, Tomas
Umeobika, Ugochukwu
Trembleau, Laurent
Bent, Andrew
Sivonen, Kaarina
Wahlsten, Matti
Wang, Hao
Rizzi, Ermano
De Bellis, Gianluca
Naismith, James
Jaspars, Marcel
Liu, Xinyu
Houssen, Wael
Fewer, David Peter

February 2017

Acknowledgements This work was supported by funding of the Academy of Finland (259505), Helsinki Uni...

Biochemical Characterization of a Cyanobactin Arginine-N-Prenylase from the Autumnalamide Biosynthetic Pathway

Clemente, Claudia
Johnson, Nicholas Ross
Ouyang, Xiaodan
Popin, Rafael V.
DallʼAngelo, Sergio
Wahlsten, Matti
Jokela, Jouni
Colombano, Alessandro
Nardone, Brunello
Fewer, David Peter
Houssen, Wael E

November 2022

Acknowledgements This project was supported by a fellowship grant from the EPSRC (no. EP/S027246/1, ...

A New and Unusual Pathway for the Reaction of Neocarzinostatin Chromophore with Thiols. Revised Structure of the Protein-Directed Thiol Adduct

Myers, Andrew G.
Arvedson, Stephen P.
Lee, Robert W.

May 1996

Neocarzinostatin (holo-NCS) is an antitumor antibiotic comprising a nonprotein chromophore component...

Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid

Fang, Qing
Wu, Linrui
Urwald, Caroline
Mugat, Morgane
Wang, Shan
Kyeremeh, Kwaku
Philips, Carol
Law, Samantha
Zhou, Yongjun
Deng, Hai

March 2021

QF and HD are grateful to the University of Aberdeen Elphinstone Scholarship and Scottish Funding Co...

Biosynthesis of the bis-prenylated alkaloids muscoride A and B

Mattila, Antti
Andsten, Rose-Marie
Jumppanen, Mikael
Assante, Michele
Jokela, Jouni
Wahlsten, Matti
Mikula, Kornelia M
Sigindere, Cihad
Kwak, Daniel H.
Gugger, Muriel
Koskela, Harri
Sivonen, Kaarina
Liu, Xinyu
Yli-Kauhaluoma, Jari
Iwaï, Hideo
Fewer, David

December 2019

Prenylation is a common step in the biosynthesis of many natural products and plays an important rol...

Genome Mining Discovery of a New Benzazepine Alkaloid Pseudofisnin A from the Marine Fungus <i>Neosartorya pseudofischeri</i> F27-1

Xiao-Xin Xue
Lin Chen
Man-Cheng Tang

October 2022

l-Kynurenine (Kyn) is an intermediate in the kynurenine pathway and is also found to be a building b...

Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase

Yang, Ming
Li, Wanlu
Zhou, Lin
Lin, Xiao
Zhang, Wenyu
Shen, Yaoyao
Deng, Hai
Lin, Hou-Wen
Zhou, Yongjun

September 2023

Funding Information: This work received financial support from the National Natural Science Foundati...

Total synthesis of noricumazole B establishes D-arabinose as glycan unit

Barbier, Jenny
Gerth, Klaus
Jansen, Rolf
Kirschning, Andreas

January 2012

The total synthesis of noricumazole B, a secondary metabolite from myxobacteria, was achieved. It es...

Profiling Natural Product Biosynthesis

Frankel, Brenda A
McCafferty, Dewey G

March 2004

AbstractNatural products are a rich source of therapeutics; however, artificially reengineering the ...

Neocarzinostatin chromophore: structural, mechanistic, and synthetic studies

Proteau, Philip Jerome

January 1990

Neocarzinostatin chromophore 1 is the active component of the antitumor antibiotic neocarzinostatin...

Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

Abstract

Extracted data

Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

Abstract

Extracted data

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