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Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

Green, J
Ikram, M
Vyas, J
Patel, N
Proby, CM
Ghali, L
Leigh, IM
O'Toole, EA
Storey, A

Publication date

December 2015

DOI

10.1038/sj.bjc.6603135

Publisher

Springer Science and Business Media LLC

Journal

British Journal of Cancer

Abstract

This research was supported by funding from Cancer Research UK and AICR Grant 03-315 to EA O’Toole

Extracted data

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Cichoń, Monika A.
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Cerio, Rino
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O'Toole, Edel A.

February 2011

Expression of Axl, a receptor tyrosine kinase, is increased in cutaneous squamous cell carcinoma (SC...

Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

Green, J.
Ikram, M.
Vyas, J.
Patel, N.
Proby, C.
Ghali, L.
Leigh, I.
O'Toole, E.
Storey, A.
Green, J.
Ikram, M.
Vyas, J.
Patel, N.
Proby, C.
Ghali, L.
Leigh, I.
O'Toole, E.
Storey, A.

January 2006

The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorl...

Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

Green, J.
Ikram, Mohammed S.
Vyas, J.
Patel, N.
Proby, Charlotte M.
Ghali, Lucy
Leigh, Irene M.
O'Toole, Edel A.
Storey, Alan

May 2006

The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorl...

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

O'Bryan, J P
Frye, R A
Cogswell, P C
Neubauer, A
Kitch, B
Prokop, C
Espinosa, R
Le Beau, M M
Earp, H S
Liu, E T

January 1991

Using a sensitive transfection-tumorigenicity assay, we have isolated a novel transforming gene from...

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

O'Bryan, J P
Frye, R A
Cogswell, P C
Neubauer, A
Kitch, B
Prokop, C
Espinosa, R
Le Beau, M M
Earp, H S
Liu, E T

January 1991

Using a sensitive transfection-tumorigenicity assay, we have isolated a novel transforming gene from...

Axl Promotes Cutaneous Squamous Cell Carcinoma Survival through Negative Regulation of Pro-Apoptotic Bcl-2 Family Members

Papadakis, Emmanouil S.
Cichoń, Monika A.
Vyas, Jashmin J.
Patel, Nakul
Ghali, Lucy
Cerio, Rino
Storey, Alan
O'Toole, Edel A.

February 2011

Expression of Axl, a receptor tyrosine kinase, is increased in cutaneous squamous cell carcinoma (SC...

Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression

Anne Von Mässenhausen

December 2016

Head and neck squamous cell carcinoma (HNSCC) remains a clinical challenge and identification of nov...

Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression

Anne von Mässenhausen
Johannes Brägelmann
Hannah Billig
Britta Thewes
Angela Queisser
Wenzel Vogel
Glen Kristiansen
Andreas Schröck
Friedrich Bootz
Peter Brossart
Jutta Kirfel
Sven Perner

December 2016

Head and neck squamous cell carcinoma (HNSCC) remains a clinical challenge and identification of nov...

Human Cutaneous Melanomas Lacking MITF and Melanocyte Differentiation Antigens Express a Functional Axl Receptor Kinase

Sensi, Marialuisa
Catani, Mara
Castellano, Giancarlo
Nicolini, Gabriella
Alciato, Federica
Tragni, Gabrina
De Santis, Giuseppina
Bersani, Ilaria
Avanzi, Giancarlo
Tomassetti, Antonella
Canevari, Silvana
Anichini, Andrea

December 2011

Axl, a member of the TAM (Tyro3, Axl, Mer) family of receptor tyrosine kinases, displays an increasi...

The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma

Fleuren, E.D.G.
Hillebrandt-Roeffen, M.H.
Flucke, U.E.
Loo, D.M.W.M. te
Boerman, O.C.
Graaf, W.T.A. van der
Versleijen-Jonkers, Y.M.H.

January 2014

Item does not contain fulltextNew targets for Ewing sarcoma (ES) patients are urgently needed. There...

Targeting AXL and the DNA damage response pathway as a novel therapeutic strategy in melanoma

Karlsen, Karine Flem
McFadden, Erin
Omar, Nasrin
Haugen, Mads Haugland
Øy, Geir Frode
Ryder, Truls
Gullestad, Hans Petter
Hermann, Robert
Mælandsmo, Gunhild Mari
Flørenes, Vivi Ann

January 2019

Receptor tyrosine kinase AXL is found upregulated in various types of cancer, including melanoma, an...

The role of Axl in melanoma metastasis

Kang, Jing

January 2015

Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma me...

Human Cutaneous Melanomas Lacking MITF and Melanocyte Differentiation Antigens Express a Functional Axl Receptor Kinase

Sensi, Marialuisa
Catani, Mara
Castellano, Giancarlo
Nicolini, Gabriella
Alciato, Federica
Tragni, Gabrina
De Santis, Giuseppina
Bersani, Ilaria
Avanzi, Giancarlo
Tomassetti, Antonella
Canevari, Silvana
Anichini, Andrea

December 2011

Axl, a member of the TAM (Tyro3, Axl, Mer) family of receptor tyrosine kinases, displays an increasi...

Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast

Berclaz, G.
Altermatt, H. J.
Rohrbach, V.
Kieffer, I.
Dreher, E.
Andres, A.-C

August 2017

Summary Background: Axl, a member of a family of receptor tyrosine kinases characterized by an extra...

Targeting AXL and the DNA damage response pathway as a novel therapeutic strategy in melanoma

Karlsen, Karine Flem
McFadden, Erin
Omar, Nasrin
Haugen, Mads Haugland
Øy, Geir Frode
Ryder, Truls
Gullestad, Hans Petter
Hermann, Robert
Mælandsmo, Gunhild Mari
Flørenes, Vivi Ann

January 2020

Receptor tyrosine kinase AXL is found upregulated in various types of cancer, including melanoma, an...

Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members

Papadakis, Emmanouil S.
Cichoń, Monika A.
Vyas, Jashmin J.
Patel, Nakul
Ghali, Lucy
Cerio, Rino
Storey, Alan
O'Toole, Edel A.

February 2011

Expression of Axl, a receptor tyrosine kinase, is increased in cutaneous squamous cell carcinoma (SC...