Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukemia
- Law, PJ
- Berndt, SI
- Speedy, HE
- Camp, NJ
- Sava, GP
- Skibola, CF
- Holroyd, A
- Joseph, V
- Sunter, NJ
- Nieters, A
- Bea, S
- Monnereau, A
- Martin-Garcia, D
- Goldin, LR
- Clot, G
- Teras, LR
- Quintela, I
- Birmann, BM
- Jayne, S
- Cozen, W
- Majid, A
- Smedby, KE
- Dearden, C
- Brooks-Wilson, AR
- Hall, AG
- Purdue, MP
- Mainou-Fowler, T
- Vajdic, CM
- Jackson, GH
- Cocco, P
- Marr, H
- Zhang, Y
- Zheng, T
- Giles, GG
- Lawrence, C
- Call, TG
- Liebow, M
- Melbye, M
- Glimelius, B
- Mansouri, L
- Glenn, M
- Curtin, K
- Diver, WR
- Link, BK
- Conde, L
- Bracci, PM
- Holly, EA
- Jackson, RD
- Tinker, LF
- Benavente, Y
- Boffetta, P
- Brennan, P
- Maynadie, M
- McKay, J
- Albanes, D
- Weinstein, S
- Wang, Z
- Caporaso, NE
- Morton, LM
- Severson, RK
- Riboli, E
- Vineis, P
- Vermeulen, RCH
- Southey, MC
- Milne, RL
- Clavel, J
- Topka, S
- Spinelli, JJ
- Kraft, P
- Grazia Ennas, M
- Summerfield, G
- Ferri, GM
- Harris, RJ
- Miligi, L
- Pettitt, AR
- North, KE
- Allsup, DJ
- Fraumeni, JF
- Bailey, JR
- Offit, K
- Pratt, G
- Hjalgrim, H
- Pepper, C
- Chanock, SJ
- Fegan, C
- Rosenquist, R
- De Sanjose, S
- Carracedo, A
- Dyer, MJS
- Catovsky, D
- Campo, E
- Cerhan, JR
- Allan, JM
- Rothman, N
- Houlston, R
- Slager, S
DOIAbstract
Several chronic lymphocytic leukemia (CLL) susceptibility loci have been reported, however much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1000 Genomes and UK10K data, totaling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P = 5.04x10-13), 1q42.13 (rs41271473, P = 1.06x10-10), 4q24 (rs71597109, P = 1.37x10-10), 4q35.1 (rs57214277, P = 3.69x10-8), 6p21.31 (rs3800461, P = 1.97x10-8), 11q23.2 (rs61904987, P = 2.64x10-11), 18q21.1 (rs1036935, P = 3.27x10-8), 19p13.3 (rs7254272, P = 4.67x10-8) and 22q13.33 (rs140522, P = 2.70x10-9). These new and established risk loci map to ar...
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