Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension: A Pathophysiological Continuum
- Opitz, CF
- Hoeper, MM
- Gibbs, JS
- Kaemmerer, H
- Pepke-Zaba, J
- Coghlan, JG
- Scelsi, L
- D'Alto, M
- Olsson, KM
- Ulrich, S
- Scholtz, W
- Schulz, U
- Grünig, E
- Vizza, CD
- Staehler, G
- Bruch, L
- Huscher, D
- Pittrow, D
- Rosenkranz, S
DOIAbstract
BACKGROUND: Pulmonary hypertension (PH) is hemodynamically classified as pre-capillary (as seen in idiopathic pulmonary arterial hypertension [IPAH]) or post-capillary (as seen in heart failure with preserved ejection fraction [HFpEF]). Overlaps between these conditions exist. Some patients present with risk factors for left heart disease but pre-capillary PH, whereas patients with HFpEF may have combined pre- and post-capillary PH. OBJECTIVES: This study sought to further characterize similarities and differences among patient populations with either PH-HFpEF or IPAH. METHODS: We used registry data to analyze clinical characteristics, hemodynamics, and treatment responses in patients with typical IPAH (<3 risk factors for left heart diseas...
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