Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly expressed in adipose tissue. Our aim was to identify molecular targets and functions of SIK2 in adipocytes, and to address the role of PKA-mediated phosphorylation of SIK2 on Ser358. Modulation of SIK2 in adipocytes resulted in altered phosphorylation of CREB-regulated transcription co-activator 2 (CRTC2), CRTC3 and class IIa histone deacetylase 4 (HDAC4). Furthermore, CRTC2, CRTC3, HDAC4 and protein phosphatase 2A (PP2A) interacted with SIK2, and the binding of CRTCs and PP2A to wild-type but not Ser358Ala SIK2, was reduced by cAMP elevation. Silencing of SIK2 resulted in reduced GLUT4 (also known as SLC2A4) protein levels, whereas cells trea...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Cyclic AMP promotes chronic expression of target genes mainly by protein kinase A–dependent activati...
Obesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly i...
Adipose tissue does not only store and release energy in response to hormones, it is also known as a...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly e...
Cyclic AMP promotes chronic expression of target genes mainly by protein kinase A–dependent activati...
Obesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly i...
Adipose tissue does not only store and release energy in response to hormones, it is also known as a...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kina...