Add to ORKGWe report an experimental study of the influences of the fixed charge and bulk ionic concentrations on the conduction of biological ion channels, and we consider the results within the framework of the ionic Coulomb blockade model of permeation and selectivity. Voltage clamp recordings were used to investigate the Na$^+$/Ca$^{2+}$ anomalous mole fraction effect (AMFE) exhibited by the bacterial sodium channel NaChBac and its mutants. Site-directed mutagenesis was used to study the effect of either increasing or decreasing the fixed charge in their selectivity filters for comparison with the predictions of the Coulomb blockade model. The model was found to describe well some aspects of the experimental (divalent blockade and AMFE) and simula...
Ion channel selectivity is essential for their function, yet the molecular basis of a channel's abil...
Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes, but their exceptional siz...
Abstract: Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes but their except...
We report an experimental study of the influences of the fixed charge and bulk ionic concentrations ...
Abstract Background. The selectivity of biological cation channels is defined by a short, narrow sel...
Mutation-induced transformations of conductivity and selectivity in NaChBac bacterial channels are s...
The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulom...
Biological ion channels are protein nanotubes embedded in, and passing through, the bilipid membrane...
A discrete electrostatic/diffusion model has been developed to describe the selective permeation of ...
The highly selective permeation of ions through biological ion channels is an unsolved problem of no...
The highly selective permeation of ions through biological ion channels is an unsolved problem of no...
The highly selective permeation of ions through biological ion channels can be described and explain...
Ionic Coulomb blockade (ICB) is an electrostatic phenomenon recently discovered in low-capacitance i...
Ion channel selectivity is essential for their function, yet the molecular basis of a channel's abil...
The flow of ions through a biological ion channel can be considered as transitions between occupied ...
Ion channel selectivity is essential for their function, yet the molecular basis of a channel's abil...
Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes, but their exceptional siz...
Abstract: Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes but their except...
We report an experimental study of the influences of the fixed charge and bulk ionic concentrations ...
Abstract Background. The selectivity of biological cation channels is defined by a short, narrow sel...
Mutation-induced transformations of conductivity and selectivity in NaChBac bacterial channels are s...
The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulom...
Biological ion channels are protein nanotubes embedded in, and passing through, the bilipid membrane...
A discrete electrostatic/diffusion model has been developed to describe the selective permeation of ...
The highly selective permeation of ions through biological ion channels is an unsolved problem of no...
The highly selective permeation of ions through biological ion channels is an unsolved problem of no...
The highly selective permeation of ions through biological ion channels can be described and explain...
Ionic Coulomb blockade (ICB) is an electrostatic phenomenon recently discovered in low-capacitance i...
Ion channel selectivity is essential for their function, yet the molecular basis of a channel's abil...
The flow of ions through a biological ion channel can be considered as transitions between occupied ...
Ion channel selectivity is essential for their function, yet the molecular basis of a channel's abil...
Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes, but their exceptional siz...
Abstract: Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes but their except...