Dissolution Rates of Mangosteen (Garcinia mangostana L.) Pericarps Extract Granules in Synthetic Human Gastrointestinal Fluid

Mangosteen (Garcinia mangostana L.) pericarps contain prenylated xanthone derivates, which exhibit some pharmacological activities, such as antiinflammatory, antihistamine, antibacterial, antivirus, antifungal, antioxidant, and antiulcerogenic. The purpose of this research was to study the dissolution rates of mangosteen pericarp extract granules in synthetic human gastrointestinal fluid at various pH and temperatures, which include experimental and modeling works. The granules were prepared by wet granulation of methanol extracts of mangosteen pericarps with addition of 25% w/v Arabic gum and 5% w/v maltodextrin. Dissolution rate study was performed by dissolving 0.5 g granules in 500 mL of 0.02M phosphate buffer solution with constant agitation at various pH (5.5, 6, 6.5, 7 and 7.5) and temperatures (30, 37 and 40oC) for two hours. Every 20 minutes, a liquid sample was withdrawn from the system for xanthone analysis. The results showed that mangosteen pericarps granules dissolution rates increased with pH under acidic condition. At pH 7.5 (basic condition), the dissolution rate was faster than that at pH 7. As expected, the dissolution rates were higher at higher temperatures. The semi empirical Korsmeyer-Peppas model showed its superiority over other models to predict the mangosteen pericarps granules dissolution rates. However, the mass transfer model proposed in this work also agreed well with the experimental data with error percentages closely similar to that of Korsmeyer-Peppas model