Targeting chemotherapeutic resistance in breast cancer

Access restricted, at author's request until June 20, 2021 due to proprietary information.The Bcl-2 family of proteins regulate cell survival and are targets for cancer therapy. This protein family has also been implicated in chemotherapeutic resistance, the cause of approximately 90% of treatment failure in advanced cancer. We analyzed the expression and the role of the Bcl-2 proteins in chemotherapy resistant breast cancer cells. Further, we investigated the role of a new class of molecules developed in our laboratory that target Bcl-2. These compounds effectively induced death in chemotherapy resistant breast cancer cells and reduced their ability to form colonies. Therefore, our studies have identified a group of compounds that have the potential to treat chemotherapy resistant breast cancer