This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at: http://www.sciencedirect.com/science/journal/00062952.Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a\ud soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and\ud 3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂\ud upon addition of NADPH. Addition of substrate had little effect on H₂O₂ production.\ud Two common FMO2 (the major isoform in the lung) genetic polymorphisms, S195L and\ud N413K, were examined for generation of H₂O₂. FMO2 S195L exhibited higher\ud “leakage”, producing much greater amounts of H₂O₂...
Several full-length clones encoding the human and guinea pig orthologs of flavin-containing monooxyg...
Importance of the field: Flavin-containing monooxygenases (FMOs) metabolize a number of therapeutic ...
1. The review focuses on genetic variants of human flavin-containing monooxygenase 3 (FMO3) and thei...
Graduation date: 1999Flavin-containing monooxygenase (FMO, EC1.14.13.8) comprises a family of\ud xen...
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published arti...
The flavin-containing monooxygenase gene family (FMO1–6) in humans encodes five functional isoforms ...
Introduction: Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. / A...
Flavin-containing monooxygenases (FMOs) are, after cytochromes P450, the most important monooxygenas...
Presented bachelor thesis is an overview of the most important facts about flavin-containing monooxy...
NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Pharma...
Flavin-containing monooxygenases (FMOs) are, after cytochromes P450, the most important monooxygenas...
This review summarizes recent information concerning the pharmacological and toxicological significa...
We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucid...
cDNA clones that code for a pig and human flavin-containing monooxygenase (FMO) have been isolated. ...
Microsomal flavin-containing monooxygenase catalyzes the oxygenation of many different nucleophilic ...
Several full-length clones encoding the human and guinea pig orthologs of flavin-containing monooxyg...
Importance of the field: Flavin-containing monooxygenases (FMOs) metabolize a number of therapeutic ...
1. The review focuses on genetic variants of human flavin-containing monooxygenase 3 (FMO3) and thei...
Graduation date: 1999Flavin-containing monooxygenase (FMO, EC1.14.13.8) comprises a family of\ud xen...
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published arti...
The flavin-containing monooxygenase gene family (FMO1–6) in humans encodes five functional isoforms ...
Introduction: Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. / A...
Flavin-containing monooxygenases (FMOs) are, after cytochromes P450, the most important monooxygenas...
Presented bachelor thesis is an overview of the most important facts about flavin-containing monooxy...
NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Pharma...
Flavin-containing monooxygenases (FMOs) are, after cytochromes P450, the most important monooxygenas...
This review summarizes recent information concerning the pharmacological and toxicological significa...
We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucid...
cDNA clones that code for a pig and human flavin-containing monooxygenase (FMO) have been isolated. ...
Microsomal flavin-containing monooxygenase catalyzes the oxygenation of many different nucleophilic ...
Several full-length clones encoding the human and guinea pig orthologs of flavin-containing monooxyg...
Importance of the field: Flavin-containing monooxygenases (FMOs) metabolize a number of therapeutic ...
1. The review focuses on genetic variants of human flavin-containing monooxygenase 3 (FMO3) and thei...