Tissue-specific progenitor cells emerge during development to expand and differentiate into the multiple cell lineages that populate the embryo. Appropriate differentiation of these precursor cells requires coordinated expression of numerous lineage-specific genes and repression of alternative fate programs. Epigenetic regulators are enzymes capable of activating or silencing large genomic domains by altering histone modifications, DNA methylation status and chromatin organization. Although differentiating progenitor cells undergo epigenetic changes and epigenetic factors are required for appropriate cell behavior, the precise mechanism of how these proteins influence cell fate remains unclear. In this dissertation, I examine the role of hi...
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structur...
SummaryEpigenetic mechanisms have been proposed to play crucial roles in mammalian development, but ...
AbstractEpigenetic modification as an intrinsic fine-tune program cooperates with key transcription ...
Tissue-specific progenitor cells emerge during development to expand and differentiate into the mult...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
SummaryDifferentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study ...
Disruptions in cardiac development cause congenital heart disease, the most prevalent and deadly con...
Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study the reg...
BACKGROUND: Epigenetic mechanisms regulate gene expression patterns affecting cell function and diff...
Coronary vessel development is a crucial part of heart development requiring the interplay of the ep...
Epigenetic regulation of gene expression is essential for faithful cellular specification during emb...
Histone deacetylase 1 (HDAC1) functions as the catalytic core of multiprotein corepressor complexes ...
HDACs can modify the structure and function of chromatin to regulate gene expression and can also mo...
© 2012 Dr. Christian OrlowskiThe epigenetic mechanisms underlying the nuclear plasticity of embryoni...
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structur...
SummaryEpigenetic mechanisms have been proposed to play crucial roles in mammalian development, but ...
AbstractEpigenetic modification as an intrinsic fine-tune program cooperates with key transcription ...
Tissue-specific progenitor cells emerge during development to expand and differentiate into the mult...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
SummaryDifferentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study ...
Disruptions in cardiac development cause congenital heart disease, the most prevalent and deadly con...
Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study the reg...
BACKGROUND: Epigenetic mechanisms regulate gene expression patterns affecting cell function and diff...
Coronary vessel development is a crucial part of heart development requiring the interplay of the ep...
Epigenetic regulation of gene expression is essential for faithful cellular specification during emb...
Histone deacetylase 1 (HDAC1) functions as the catalytic core of multiprotein corepressor complexes ...
HDACs can modify the structure and function of chromatin to regulate gene expression and can also mo...
© 2012 Dr. Christian OrlowskiThe epigenetic mechanisms underlying the nuclear plasticity of embryoni...
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structur...
SummaryEpigenetic mechanisms have been proposed to play crucial roles in mammalian development, but ...
AbstractEpigenetic modification as an intrinsic fine-tune program cooperates with key transcription ...