Cancer is a disease that develops over decades as result of acquisition of abnormalities in the genomes of otherwise normal cells. Acquired genomic heterogeneity in populations of cells within tissues allows cell-level Darwinian evolution that selects abnormal cellular genotypes encoding neoplastic (new benign growth), and in some cases cancerous (invasion within tissues and metastasis across tissues) cellular phenotypes. I studied neoplastic evolution over time in vivo in the pre-malignant condition Barrett\u27s esophagus to address the puzzling clinical phenomenon that 90–95% of individuals with Barrett\u27s stay benign over decades compared to the remaining 5–10% who progress to esophageal adenocarcinoma. Some individuals with Barrett\u2...
OBJECTIVES: Most patients with Barrett’s esophagus do not progress to cancer, but those who do seem ...
In The Cancer Genome Atlas the goals were to define how to treat advanced cancers with targeted ther...
Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma ...
Cancer is a disease that develops over decades as result of acquisition of abnormalities in the geno...
Cancer is a disease that develops over decades as result of acquisition of abnormalities in the geno...
<div><p>Cancer is considered an outcome of decades-long clonal evolution fueled by acquisition of so...
Abstract Background Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been...
There is debate in the literature over the relative importance of genetic instability and clonal exp...
textabstractOBJECTIVE: To review the current knowledge on the genetic alterations involve...
abstract: Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a hum...
Oesophageal adenocarcinoma (OA) remains one of the more deadly forms of gastro-intestinal cancer wit...
Although researchers have identified genetic alterations that contribute to development of esophagea...
The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion,...
<p>(Panel A) Solid lines connect the mean amount of SGA detected across biopsies at each time point;...
textabstractThe incidence of adenocarcinoma in Barrett's esophagus has been increasing rapidly...
OBJECTIVES: Most patients with Barrett’s esophagus do not progress to cancer, but those who do seem ...
In The Cancer Genome Atlas the goals were to define how to treat advanced cancers with targeted ther...
Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma ...
Cancer is a disease that develops over decades as result of acquisition of abnormalities in the geno...
Cancer is a disease that develops over decades as result of acquisition of abnormalities in the geno...
<div><p>Cancer is considered an outcome of decades-long clonal evolution fueled by acquisition of so...
Abstract Background Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been...
There is debate in the literature over the relative importance of genetic instability and clonal exp...
textabstractOBJECTIVE: To review the current knowledge on the genetic alterations involve...
abstract: Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a hum...
Oesophageal adenocarcinoma (OA) remains one of the more deadly forms of gastro-intestinal cancer wit...
Although researchers have identified genetic alterations that contribute to development of esophagea...
The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion,...
<p>(Panel A) Solid lines connect the mean amount of SGA detected across biopsies at each time point;...
textabstractThe incidence of adenocarcinoma in Barrett's esophagus has been increasing rapidly...
OBJECTIVES: Most patients with Barrett’s esophagus do not progress to cancer, but those who do seem ...
In The Cancer Genome Atlas the goals were to define how to treat advanced cancers with targeted ther...
Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma ...