Niche cells exercise elaborate control over the behavior of many tissue-specific stem cells. However, in no system do we fully understand how niche cells are specified, develop and then begin producing the signals necessary to properly regulate stem cells. Here, we take advantage of the paradigmatic stem cell-niche system of the Drosophila testis to address these fundamental questions. We first find that the Notch signaling pathway is necessary for niche cell specification and that its activity in precursor cells prevents those cells from adopting the alternative somatic cyst cell fate. We also discover that the Notch-activating ligand, Delta, is presented from the neighboring endoderm, rather than from within the gonad “proper.” Moreover, ...
In organisms, a unique population of cells called stem cells sustains tissue homeostasis and repair....
Stem cell niches act as signaling platforms that regulate stem cell self-renewal and sustain stem ce...
Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tre...
Niche cells exercise elaborate control over the behavior of many tissue-specific stem cells. However...
Niche cells exercise elaborate control over the behavior of many tissue-specific stem cells. However...
Niche cells exercise elaborate control over the behavior of many tissue-specific stem cells. However...
SummaryStem cells are maintained and retain their capacity to continue dividing because of the influ...
Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tre...
Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tre...
Here we show that multiple modes of Notch signaling activation specify the complexity of spatial cel...
All multicellular organisms constantly need to replace aged or damaged cells. This vital task of tis...
Stem cells are fascinating, as they supply the cells that construct our adult bodies and replenish, ...
SummaryAdult stem cells reside in specialized regulatory microenvironments, or niches, where local s...
SummaryStem cells are maintained and retain their capacity to continue dividing because of the influ...
Adult stem cells reside in specialized regulatory microenvironments, or niches, where local signals ...
In organisms, a unique population of cells called stem cells sustains tissue homeostasis and repair....
Stem cell niches act as signaling platforms that regulate stem cell self-renewal and sustain stem ce...
Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tre...
Niche cells exercise elaborate control over the behavior of many tissue-specific stem cells. However...
Niche cells exercise elaborate control over the behavior of many tissue-specific stem cells. However...
Niche cells exercise elaborate control over the behavior of many tissue-specific stem cells. However...
SummaryStem cells are maintained and retain their capacity to continue dividing because of the influ...
Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tre...
Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tre...
Here we show that multiple modes of Notch signaling activation specify the complexity of spatial cel...
All multicellular organisms constantly need to replace aged or damaged cells. This vital task of tis...
Stem cells are fascinating, as they supply the cells that construct our adult bodies and replenish, ...
SummaryAdult stem cells reside in specialized regulatory microenvironments, or niches, where local s...
SummaryStem cells are maintained and retain their capacity to continue dividing because of the influ...
Adult stem cells reside in specialized regulatory microenvironments, or niches, where local signals ...
In organisms, a unique population of cells called stem cells sustains tissue homeostasis and repair....
Stem cell niches act as signaling platforms that regulate stem cell self-renewal and sustain stem ce...
Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tre...