Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. The established technique of computed tomography can detect and stage the disease with limited sensitivity and is not suitable for long-term studies due to radiation exposure. In recent years, hyperpolarized 3He (HP 3He) MRI has been studied extensively as a promising tool to assess pulmonary structural and functional parameters. This work focuses on the application of this technique to study pulmonary ventilation and perfusion disorders, with an emphasis on COPD. Two hypotheses are proposed and tested in this thesis. The first hypothesis is that microscopic changes in lung structure induced by COPD cause associated function deterioration...
Looking inside the lungs without the danger of ionizing radiation side effects became available with...
A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyper...
Both the development of accurate models of lung function and their quantitative validation can be si...
Chronic obstructive pulmonary disease (COPD) and emphysema are characterized by functional and struc...
The microstructure of the lung is complex, containing many branching airways and alveolar sacs for o...
OBJECTIVE: Hyperpolarized 3He magnetic resonance imaging (3He MRI) at 3.0 Tesla of healthy volunteer...
Lung diseases such as chronic obstructive pulmonary disease and asthma affect mil- lions of people w...
Abstract COPD is a major cause of chronic morbidity and mortality throughout the world. It is a prev...
RATIONALE AND OBJECTIVES: Emphysema and small airway obstruction are the pathological hallmarks of c...
The microstructure of the lung is complex, containing many branching airways and alveolar sacs for o...
Chronic obstructive pulmonary disease (COPD) and emphysema are characterized by functional and struc...
OBJECTIVE: Hyperpolarized 3He magnetic resonance imaging (3He MRI) at 3.0 Tesla of healthy volunteer...
Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death worldwide and account...
During the past several years there has been extensive development and application of hyperpolarized...
Looking inside the lungs without the danger of ionizing radiation side effects became available with...
Looking inside the lungs without the danger of ionizing radiation side effects became available with...
A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyper...
Both the development of accurate models of lung function and their quantitative validation can be si...
Chronic obstructive pulmonary disease (COPD) and emphysema are characterized by functional and struc...
The microstructure of the lung is complex, containing many branching airways and alveolar sacs for o...
OBJECTIVE: Hyperpolarized 3He magnetic resonance imaging (3He MRI) at 3.0 Tesla of healthy volunteer...
Lung diseases such as chronic obstructive pulmonary disease and asthma affect mil- lions of people w...
Abstract COPD is a major cause of chronic morbidity and mortality throughout the world. It is a prev...
RATIONALE AND OBJECTIVES: Emphysema and small airway obstruction are the pathological hallmarks of c...
The microstructure of the lung is complex, containing many branching airways and alveolar sacs for o...
Chronic obstructive pulmonary disease (COPD) and emphysema are characterized by functional and struc...
OBJECTIVE: Hyperpolarized 3He magnetic resonance imaging (3He MRI) at 3.0 Tesla of healthy volunteer...
Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death worldwide and account...
During the past several years there has been extensive development and application of hyperpolarized...
Looking inside the lungs without the danger of ionizing radiation side effects became available with...
Looking inside the lungs without the danger of ionizing radiation side effects became available with...
A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyper...
Both the development of accurate models of lung function and their quantitative validation can be si...