Help provided by CD4 T lymphocytes is known to be required for the priming and maintenance of cytotoxic CD8 T lymphocytes (CTLs) during a primary infection. However, little is known about the contribution of CD4 T cell help (T H) to either the primary CD8 T cell response during Listeria monocytogenes infection or to the recall response mounted by memory CD8 T cells against secondary infection. Therefore, we began this investigation by first examining the role of CD4 T cells during a primary L. monocytogenes infection. We next analyzed the role of TH in the generation of antigen (Ag)-specific CD8 T cell memory by utilizing a heterologous prime-boost strategy which enabled the evaluation of Ag-specific recall responses. While we discovered th...
While CD8+ memory T cells can promote long-lived protection from secondary exposure to intracellular...
Infectious diseases invoke varying types of adaptive immune responses that are characterized by the ...
The requirements for the generation of fully competent long-lived memory CD8 T cells and in particul...
Help provided by CD4 T lymphocytes is known to be required for the priming and maintenance of cytoto...
Listeria monocytogenes (Lm) infection induces robust CD8 T cell responses, which play a critical rol...
Mounting evidence suggests that the mechanisms that regulate T cell proliferation, acquisition of ef...
The generation of immunological memory is crucial for the establishment of protection against second...
Primary and secondary (boosted) memory CD8 T cells exhibit differences in gene expression, phenotype...
SummaryThe CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimal...
Listeria monocytogenes (LM) is an enteroinvasive pathogen and the cause of listeriosis, a highly fat...
<p>The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens...
The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help ...
CD8 T lymphocytes are crucial for the elimination of many intracellular pathogens. Many pathogens in...
Both CD4(+) T cell help and IL-2 have been postulated to program activated CD8(+) T cells for memo...
Intracellular pathogens are capable of inducing vigorous CD8+ T cell responses. However, we do not e...
While CD8+ memory T cells can promote long-lived protection from secondary exposure to intracellular...
Infectious diseases invoke varying types of adaptive immune responses that are characterized by the ...
The requirements for the generation of fully competent long-lived memory CD8 T cells and in particul...
Help provided by CD4 T lymphocytes is known to be required for the priming and maintenance of cytoto...
Listeria monocytogenes (Lm) infection induces robust CD8 T cell responses, which play a critical rol...
Mounting evidence suggests that the mechanisms that regulate T cell proliferation, acquisition of ef...
The generation of immunological memory is crucial for the establishment of protection against second...
Primary and secondary (boosted) memory CD8 T cells exhibit differences in gene expression, phenotype...
SummaryThe CD8+ memory T cell population is heterogeneous, and it is unclear which subset(s) optimal...
Listeria monocytogenes (LM) is an enteroinvasive pathogen and the cause of listeriosis, a highly fat...
<p>The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens...
The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help ...
CD8 T lymphocytes are crucial for the elimination of many intracellular pathogens. Many pathogens in...
Both CD4(+) T cell help and IL-2 have been postulated to program activated CD8(+) T cells for memo...
Intracellular pathogens are capable of inducing vigorous CD8+ T cell responses. However, we do not e...
While CD8+ memory T cells can promote long-lived protection from secondary exposure to intracellular...
Infectious diseases invoke varying types of adaptive immune responses that are characterized by the ...
The requirements for the generation of fully competent long-lived memory CD8 T cells and in particul...