University of Minnesota Ph.D. dissertation. October 2015. Major: Integrative Biology and Physiology. Advisors: Alessandro Bartolomucci, John Osborn. 1 computer file (PDF); ix, 134 pages.Obesity is a major public health problem; in the U.S. nearly one third of the population is obese. The adipose tissue is innervated by the sympathetic nervous system (SNS), which regulates fat mass by playing a key role in initiating lipolysis and regulating lipid mobilization. TLQP-21, a 21 amino acid peptide encoded by the pre-pro-peptide VGF (non acronymic) expressed in the brain and sympathetic neurons innervating the adipose organ. Complement 3a receptor 1, C3aR1, is the target receptor for TLQP-21. Based on previous finding where peripheral TLQP-21 de...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
Interorgan communication mediated by secreted proteins is often disrupted in obesity, leading to ins...
TLQP-21 and TLQP-62, two peptides encoded by the VGF (non-acronymic) gene product, are expressed in ...
AbstractRecently, we demonstrated that TLQP-21 triggers lipolysis and induces resistance to obesity ...
Objectives: Obesity is characterized by excessive fat mass and is associated with serious diseases s...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
TLQP-21, a VGF-encoded peptide is emerging as a novel target for obesity-associated disorders. TLQP-...
Over the last century, the United States has experienced a shift from underweight malnutrition malad...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
Metabolic syndrome is emerging as a global epidemic that increases the risk for type 2 diabetes, car...
Obesity results from expansion of white adipose tissue. The inability of white adipose tissue to ade...
Expansion of visceral adipose tissue correlates with the metabolic syndrome and increased cardiovasc...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
Interorgan communication mediated by secreted proteins is often disrupted in obesity, leading to ins...
TLQP-21 and TLQP-62, two peptides encoded by the VGF (non-acronymic) gene product, are expressed in ...
AbstractRecently, we demonstrated that TLQP-21 triggers lipolysis and induces resistance to obesity ...
Objectives: Obesity is characterized by excessive fat mass and is associated with serious diseases s...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
TLQP-21, a VGF-encoded peptide is emerging as a novel target for obesity-associated disorders. TLQP-...
Over the last century, the United States has experienced a shift from underweight malnutrition malad...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
Metabolic syndrome is emerging as a global epidemic that increases the risk for type 2 diabetes, car...
Obesity results from expansion of white adipose tissue. The inability of white adipose tissue to ade...
Expansion of visceral adipose tissue correlates with the metabolic syndrome and increased cardiovasc...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
Interorgan communication mediated by secreted proteins is often disrupted in obesity, leading to ins...