University of Minnesota Ph.D. dissertation. April 2009. Major: Pharmacology. Advisor: Peter Bitterman, M.D. 1 computer file (PDF); xv, 139 pages.Cancer is currently the 2nd leading cause of death in the U.S., responsible for approximately one quarter of the annual death rate. While cancer is genetically diverse, we suspect there may be common components of the cellular machinery where oncogenic signals converge, and that these critical regulatory nodes may represent molecular targets for new therapies. My approach derives from recent work on human breast and lung carcinoma, and murine models of lymphoid malignancies; which identify the cap-dependent protein synthesis machinery as a critical point of convergence and amplification of oncogeni...
Translation initiation of mRNAs is regulated by the PI3K/Akt/mTOR signalling pathway through the euk...
Maintenance of cell homeostasis and regulation of cell proliferation depend importantly on regulatin...
Targeting the translational machinery has emerged as a promising therapeutic option for cancer treat...
University of Minnesota M.S. thesis. August 2012. Major: Medicinal Chemistry. Advisors:Dr. Patrick H...
Introduction: Cap-dependent mRNA translation is an essential for translation of key oncogenic protei...
University of Minnesota Ph.D. dissertation. April 2010. Major: Pharmacology. Advisors: Dr. Robert A....
Elevated protein synthesis is an important feature of many cancer cells and often arises as a conseq...
University of Minnesota Ph.D. dissertation. June 2009. Major: Microbiology, Immunology and Cancer Bi...
Translation initiation factors are over-expressed and/or activated in many human cancers and may con...
none2The eukaryotic initiation factor 4E (eIF4E) is a key regulator of protein translation whose fun...
Summary: The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancie...
Genetically engineered mouse models are powerful tools for studying cancer genes and validating targ...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
BackgroundProtein synthesis is tightly regulated and alterations to translation are characteristic o...
Translation initiation plays a critical role in the regulation of cell growth and tumorigenesis. We ...
Translation initiation of mRNAs is regulated by the PI3K/Akt/mTOR signalling pathway through the euk...
Maintenance of cell homeostasis and regulation of cell proliferation depend importantly on regulatin...
Targeting the translational machinery has emerged as a promising therapeutic option for cancer treat...
University of Minnesota M.S. thesis. August 2012. Major: Medicinal Chemistry. Advisors:Dr. Patrick H...
Introduction: Cap-dependent mRNA translation is an essential for translation of key oncogenic protei...
University of Minnesota Ph.D. dissertation. April 2010. Major: Pharmacology. Advisors: Dr. Robert A....
Elevated protein synthesis is an important feature of many cancer cells and often arises as a conseq...
University of Minnesota Ph.D. dissertation. June 2009. Major: Microbiology, Immunology and Cancer Bi...
Translation initiation factors are over-expressed and/or activated in many human cancers and may con...
none2The eukaryotic initiation factor 4E (eIF4E) is a key regulator of protein translation whose fun...
Summary: The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancie...
Genetically engineered mouse models are powerful tools for studying cancer genes and validating targ...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
BackgroundProtein synthesis is tightly regulated and alterations to translation are characteristic o...
Translation initiation plays a critical role in the regulation of cell growth and tumorigenesis. We ...
Translation initiation of mRNAs is regulated by the PI3K/Akt/mTOR signalling pathway through the euk...
Maintenance of cell homeostasis and regulation of cell proliferation depend importantly on regulatin...
Targeting the translational machinery has emerged as a promising therapeutic option for cancer treat...