Accurate copying of DNA is vital for maintaining genome integrity and organismal viability. The associated 3’ to 5’ exonuclease (exo) activity of herpes simplex virus (HSV) DNA polymerase (pol) has been shown to play multiple roles in DNA replication error avoidance. The pol-associated exo activity has been shown previously to prevent nascent strand extension in the presence of damaged primer terminus by causing futile cycles of incorporation and excision of nucleotides at the damage site. To further characterize the interaction between the exo and pol domains of the HSV pol catalytic subunit, the ability of exo-deficient (exo-) and wild-type (wt) pol to extend a DNA primer on a template containing an apyrimidinic (AP) site was assayed. We ...
DNA synthesis, carried out by DNA polymerases, requires balancing speed and accuracy for faithful re...
Replicative holoenzymes exhibit rapid and processive primer extension DNA synthesis, but inefficient...
The processing of lagging-strand intermediates has not been demonstrated in vitro for herpes simplex...
ABSTRACT: The herpes polymerase−processivity factor com-plex consists of the catalytic UL30 subunit ...
Most DNA polymerases are multifunctional proteins that possess both polymerizing and exonucleolytic ...
The catalytic subunit of herpes simplex virus DNA polymerase (Pol), a member of the B family polymer...
DNA polymerase ε (Pol ε) is a replicative DNA polymerase with an associated 3'-5' exonuclease activi...
A mutagenesis system was developed for the in vivo study of the fidelity of DNA replication mediated...
Herpes Simplex Virus type 1 is an important organism not only because it is a member of a family of ...
Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA replication fide...
Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA replication fide...
AbstractThe DNA polymerase (pol) catalytic subunit of herpes simplex virus type 1, encoded by UL30, ...
INTRODUCTION: Translesion synthesis provides a mechanism whereby DNA replication can be completed in...
Genetic and biochemical studies have shown that the products of the herpes simplex virus type 1 (HSV...
Archaeal family B polymerases bind tightly to the deaminated bases uracil and hypoxanthine in single...
DNA synthesis, carried out by DNA polymerases, requires balancing speed and accuracy for faithful re...
Replicative holoenzymes exhibit rapid and processive primer extension DNA synthesis, but inefficient...
The processing of lagging-strand intermediates has not been demonstrated in vitro for herpes simplex...
ABSTRACT: The herpes polymerase−processivity factor com-plex consists of the catalytic UL30 subunit ...
Most DNA polymerases are multifunctional proteins that possess both polymerizing and exonucleolytic ...
The catalytic subunit of herpes simplex virus DNA polymerase (Pol), a member of the B family polymer...
DNA polymerase ε (Pol ε) is a replicative DNA polymerase with an associated 3'-5' exonuclease activi...
A mutagenesis system was developed for the in vivo study of the fidelity of DNA replication mediated...
Herpes Simplex Virus type 1 is an important organism not only because it is a member of a family of ...
Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA replication fide...
Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA replication fide...
AbstractThe DNA polymerase (pol) catalytic subunit of herpes simplex virus type 1, encoded by UL30, ...
INTRODUCTION: Translesion synthesis provides a mechanism whereby DNA replication can be completed in...
Genetic and biochemical studies have shown that the products of the herpes simplex virus type 1 (HSV...
Archaeal family B polymerases bind tightly to the deaminated bases uracil and hypoxanthine in single...
DNA synthesis, carried out by DNA polymerases, requires balancing speed and accuracy for faithful re...
Replicative holoenzymes exhibit rapid and processive primer extension DNA synthesis, but inefficient...
The processing of lagging-strand intermediates has not been demonstrated in vitro for herpes simplex...