In the cardiac microenvironment, cardiomyocytes (CMs) are embedded in an aligned and structured extracellular matrix (ECM) to maintain the coordinated contractile function of the heart. The cardiac fibroblast (cFB) is the main cell type responsible for producing and remodeling this matrix. In cardiac diseases, however, adverse remodeling and CM death may lead to deterioration of the aligned myocardial structure. Here, we present an in vitro cardiac model system with uniaxial and biaxial constraints to induce (an)isotropy in 3D microtissues, thereby mimicking ‘healthy’ aligned and ‘diseased’ disorganized cardiac matrices. A mixture of neonatal mouse CMs and cFBs was resuspended in a collagen–matrigel hydrogel and seeded to form microtissues ...
The heart is a vital organ that pumps blood throughout the body by constantly, cyclically contractin...
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a resul...
Heart disease is the leading cause of death in many developing and industrialized countries. The los...
In the cardiac microenvironment, cardiomyocytes (CMs) are embedded in an aligned and structured extr...
IntroductionFibrosis is a hallmark of cardiac disease leading to changes in myocardial architecture ...
The myocardium is a mechanically active tissue typified by anisotropy of the resident cells [cardiom...
Engineered cardiac tissue models become increasingly important for understanding normal and diseased...
Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered...
Changes in myocyte cell shape and tissue structure are concurrent with changes in electromechanical ...
Cardiovascular disease is the leading cause of death worldwide. Due to the extremely low natural reg...
Engineered cardiac tissue models become increasingly important for understanding normal and disease ...
While adult heart muscle is the least regenerative of tissues, embryonic cardiomyocytes are prolifer...
<p>The heart is a muscular organ with a wrapping, laminar structure embedded with neural and vascula...
The heart has a dynamic mechanical environment contributed by its unique cellular composition and th...
Pathophysiological conditions, such as myocardial infarction and mechanical overload affect the mamm...
The heart is a vital organ that pumps blood throughout the body by constantly, cyclically contractin...
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a resul...
Heart disease is the leading cause of death in many developing and industrialized countries. The los...
In the cardiac microenvironment, cardiomyocytes (CMs) are embedded in an aligned and structured extr...
IntroductionFibrosis is a hallmark of cardiac disease leading to changes in myocardial architecture ...
The myocardium is a mechanically active tissue typified by anisotropy of the resident cells [cardiom...
Engineered cardiac tissue models become increasingly important for understanding normal and diseased...
Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered...
Changes in myocyte cell shape and tissue structure are concurrent with changes in electromechanical ...
Cardiovascular disease is the leading cause of death worldwide. Due to the extremely low natural reg...
Engineered cardiac tissue models become increasingly important for understanding normal and disease ...
While adult heart muscle is the least regenerative of tissues, embryonic cardiomyocytes are prolifer...
<p>The heart is a muscular organ with a wrapping, laminar structure embedded with neural and vascula...
The heart has a dynamic mechanical environment contributed by its unique cellular composition and th...
Pathophysiological conditions, such as myocardial infarction and mechanical overload affect the mamm...
The heart is a vital organ that pumps blood throughout the body by constantly, cyclically contractin...
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a resul...
Heart disease is the leading cause of death in many developing and industrialized countries. The los...