Flex-grid optical networks have evolved as a near-future deployment option to facilitate dynamic and bandwidth intense traffic demands. These networks enable capacity gains by operating on a flexible spectrum, allocating minimum required bandwidth, for a given channel configuration. It is thus important to understand the nonlinear dynamics of various high bit-rate super-channel configurations, and whether such channels should propagate homogenously (uniform channel configuration) or heterogeneously (non-uniform channel configuration), when upgrading the current static network structure to a flex-grid network. In this paper, we report on the spectrum allocation strategies based on the impact of inter-channel fiber nonlinearities, for PM-16QA...