Nickel-promoted recognition of long DNA sites by designed peptide derivatives

NOTICE: This is the peer reviewed version of the following article: Jessica Rodríguez, Jesús Mosquera, M. Eugenio Vázquez*, José L. Mascareñas* (2016), Nickel-promoted Recognition of long DNA sites by designed Peptide Derivatives. ChemEurJ., 22 (38), 13474-13477 [doi:10.1002/chem.201602783]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for selfarchivingWe describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of NiII salts. The modules consist of modified fragments of transcription factors that have been appropriately engineered to include metal-chelating His and bipyridine ligandsWe are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2015-70698-R, and CTQ2013-49317-EXP, the Xunta de Galicia GRC2013-041, the ERDF, and the European Research Council (Advanced Grant No. 340055). Support of COST Action CM1105, COST CM1306 and the orfeo-cinqa network are also kindly acknowledged. J.R. thanks the Xunta de Galicia for a PhD fellowshipS