International audienceAnion exchanger 1 (AE1) or band 3 is a membrane protein responsible for the rapid exchange of chloride for bicarbonate across the red blood cell membrane. Nine mutations leading to single amino-acid substitutions in the transmembrane domain of AE1 are associated with dominant hereditary stomatocytosis, monovalent cation leaks, and reduced anion exchange activity. We set up a stopped-flow spectrofluorometry assay coupled with flow cytometry to investigate the anion transport and membrane expression characteristics of wild-type recombinant AE1 in HEK293 cells, using an inducible expression system. Likewise, study of three stomatocytosis-associated mutations (R730C, E758K, and G796R),allowed the validation of our method. ...
Band 3, the most abundant erythrocyte membrane protein, mediates one-for-one· exchange of cr and ...
Objective. The anion exchanger gene (AE1) or band 3 encodes a chloride- bicarbonate (Cl-/ HCO3-) exc...
International audiencedRTA (distal renal tubular acidosis) and HS (hereditary spherocytosis) are two...
International audienceAnion exchanger 1 (AE1) or band 3 is a membrane protein responsible for the ra...
Anion exchanger 1 (AE1) or band 3 is a membrane protein responsible for the rapid exchange of chlori...
The abundant membrane protein AE1 normally functions as an obligate anion exchanger, with classical ...
Abstract We identified 11 human pedigrees with dominantly inherited hemolytic anemias in both the h...
Missense mutations in the erythroid band 3 protein (Anion Exchanger 1) have been associated with her...
BACKGROUND: Stomatocytoses are a group of inherited autosomal dominant hemolytic anemias and include...
International audienceMissense mutations in the erythroid band 3 protein (Anion Exchanger 1) have be...
International audienceBACKGROUND: Stomatocytoses are a group of inherited autosomal dominant hemolyt...
AE1 (SLC4A1, band 3) is a member of the SLC4 bicarbonate transporter family. This protein is the mos...
Background Stomatocytoses are a group of inherited autosomal dominant hemolytic anemias and incl...
International audienceThe anion exchanger 1 (AE1), a member of bicarbonate transporter family SLC4, ...
The crystal structure of the dimeric membrane domain of human Band 31, the red cell chloride/bicarbo...
Band 3, the most abundant erythrocyte membrane protein, mediates one-for-one· exchange of cr and ...
Objective. The anion exchanger gene (AE1) or band 3 encodes a chloride- bicarbonate (Cl-/ HCO3-) exc...
International audiencedRTA (distal renal tubular acidosis) and HS (hereditary spherocytosis) are two...
International audienceAnion exchanger 1 (AE1) or band 3 is a membrane protein responsible for the ra...
Anion exchanger 1 (AE1) or band 3 is a membrane protein responsible for the rapid exchange of chlori...
The abundant membrane protein AE1 normally functions as an obligate anion exchanger, with classical ...
Abstract We identified 11 human pedigrees with dominantly inherited hemolytic anemias in both the h...
Missense mutations in the erythroid band 3 protein (Anion Exchanger 1) have been associated with her...
BACKGROUND: Stomatocytoses are a group of inherited autosomal dominant hemolytic anemias and include...
International audienceMissense mutations in the erythroid band 3 protein (Anion Exchanger 1) have be...
International audienceBACKGROUND: Stomatocytoses are a group of inherited autosomal dominant hemolyt...
AE1 (SLC4A1, band 3) is a member of the SLC4 bicarbonate transporter family. This protein is the mos...
Background Stomatocytoses are a group of inherited autosomal dominant hemolytic anemias and incl...
International audienceThe anion exchanger 1 (AE1), a member of bicarbonate transporter family SLC4, ...
The crystal structure of the dimeric membrane domain of human Band 31, the red cell chloride/bicarbo...
Band 3, the most abundant erythrocyte membrane protein, mediates one-for-one· exchange of cr and ...
Objective. The anion exchanger gene (AE1) or band 3 encodes a chloride- bicarbonate (Cl-/ HCO3-) exc...
International audiencedRTA (distal renal tubular acidosis) and HS (hereditary spherocytosis) are two...