It is an actual and challenging issue to learn cost-sensitive models from those datasets that are with few labeled data and plentiful unlabeled data, because some time labeled data are very difficult, time consuming and/or expensive to obtain. To solve this issue, in this paper we proposed two classification strategies to learn cost-sensitive classifier from training datasets with both labeled and unlabeled data, based on Expectation Maximization (EM). The first method, Direct-EM, uses EM to build a semi-supervised classifier, then directly computes the optimal class label for each test example using the class probability produced by the learning model. The second method, CS-EM, modifies EM by incorporating misclassification cost into the p...