Pro-Inflammatory Cytokines in Nasopharyngeal Aspirate From Hospitalized Children With Respiratory Syncytial Virus Infection With or Without Rhinovirus Bronchiolitis, and Use of the Cytokines as Predictors of Illness Severity
- Díaz, Patricia V.
- Valdivia, Gonzalo
- Gaggero Brillouet, Aldo
- Bono Merino, María Rosa
- Zepeda Flores, Guillermo
- Rivas, Mabel
- Uasapud, Paola A.
- Pinto, Ricardo A.
- Boza, María Lina
- Guerrero, Julia
DOIAbstract
Artículo de publicación ISIRespiratory syncytial virus (RSV) and human rhinovirus (HRV) respiratory infection in children induce production of inflammatory interleukins (ILs) in the respiratory epithelium. As IL(s) determine the severity of illness, the purpose of this study was to identify the pro-inflammatory IL(s) that could be predictor(s) of clinical severity.One hundred and fifteen patients <2 years old with bronchiolitis due to RSV and /or HRV and 38 controls were selected from a hospital and an outpatient clinic. Clinical data of all patients were recorded. Severity was defined by the number of days with oxygen need. Nasopharyngeal aspirates (NPA) were collected to perform viral diagnosis by quantitative reverse transcription and po...
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