Gene expression changes with age in skin, adipose tissue, blood and brain
- Glass, Daniel
- Viñuela, Ana
- Davies, Matthew N
- Ramasamy, Adaikalavan
- Parts, Leopold
- Knowles, David
- Brown, Andrew Anand
- Hedman, Asa K
- Small, Kerrin S
- Buil Demur, Alfonso Alberto
- Grundberg, Elin
- Nica, Alexandra
- Di Meglio, Paola
- Nestle, Frank O
- Ryten, Mina
- Durbin, Richard
- McCarthy, Mark I
- Deloukas, Panagiotis
- Dermitzakis, Emmanouil
- Weale, Michael E
- Bataille, Veronique
- Spector, Tim D
Publication date
January 2013
DOI Publisher
Springer Science and Business Media LLCAbstract
Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age
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