Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers
- Khelwatty, Said A.
- Essapen, Sharadah
- Seddon, Alan M.
- Fan, Zhen
- Modjtahedi, Helmout
Publication date
September 2015
DOI Publisher
Springer Science and Business Media LLC ISSN
0007-0920 Citation count (estimate)
9Abstract
Our results provide a novel mechanistic insight into the development of acquired resistance to EGFR antibody-based therapy in colorectal cancer cells and justify further investigations on the therapeutic benefits of pan-HER family inhibitors in the treatment of colorectal cancer patients once acquired resistance to EGFR antibody-based therapy is developed
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