We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-free systems with the same metabolic cost. We also show that there is an optimal Hill coefficienthwhich minimizes noise and metabolic cost at fixed speeds, and an optimal thresholdKwhich minimizes noise.</jats:p
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protei...
Cells are often considered input-output devices that maximize the transmission of information by con...
<div><p>Protein noise measurements are increasingly used to elucidate biophysical parameters. Unfort...
We analyse the trade-off between the speed with which a gene can propagate information, the noise of...
Gene networks can often be interpreted as computational circuits. This article investigates the comp...
This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in term...
Genetic regulatory circuits are often regarded as precise machines that accurately determine the lev...
High accuracy of major biological processes relies on the ability of the participating enzymatic mol...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer...
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protei...
ABSTRACT: Dynamic control of enzyme expression can be an effective strategy to engineer robust metab...
<p>(A) Any transmission of signals (<i>x</i>) that could lead to an error in the output (<i>y</i>) c...
Published online: 7 March 2013The limits on maximum information that can be transferred by single ne...
In this article we demonstrate that the so-called bursting production of molecular species during ge...
<p>Number of unique phenotypes <i>U</i> accessed for different numbers of gene expression states <i>...
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protei...
Cells are often considered input-output devices that maximize the transmission of information by con...
<div><p>Protein noise measurements are increasingly used to elucidate biophysical parameters. Unfort...
We analyse the trade-off between the speed with which a gene can propagate information, the noise of...
Gene networks can often be interpreted as computational circuits. This article investigates the comp...
This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in term...
Genetic regulatory circuits are often regarded as precise machines that accurately determine the lev...
High accuracy of major biological processes relies on the ability of the participating enzymatic mol...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer...
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protei...
ABSTRACT: Dynamic control of enzyme expression can be an effective strategy to engineer robust metab...
<p>(A) Any transmission of signals (<i>x</i>) that could lead to an error in the output (<i>y</i>) c...
Published online: 7 March 2013The limits on maximum information that can be transferred by single ne...
In this article we demonstrate that the so-called bursting production of molecular species during ge...
<p>Number of unique phenotypes <i>U</i> accessed for different numbers of gene expression states <i>...
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protei...
Cells are often considered input-output devices that maximize the transmission of information by con...
<div><p>Protein noise measurements are increasingly used to elucidate biophysical parameters. Unfort...