A powerful new approach has become much more widespread and offers insights into aspects of DNA repair unattainable with billions of molecules. Single molecule techniques can be used to image, manipulate or characterize the action of a single repair protein on a single strand of DNA. This allows search mechanisms to be probed, and the effects of force to be understood. These physical aspects can dominate a biochemical reaction, where at the ensemble level their nuances are obscured. In this paper we discuss some of the many technical advances that permit study at the single molecule level. We focus on DNA repair to which these techniques are actively being applied. DNA repair is also a process that encompasses so much of what single molecul...
The cellular genetic information is encoded in double-stranded DNA. The separation of DNA strands in...
To combat the destructive effects of damage to DNA, different repair mechanisms play central roles. ...
Numerous agents of endogenous and exogenous origin damage DNA in our genome. There are several DNA-r...
A powerful new approach has become much more widespread and offers insights into aspects of DNA repa...
Ubiquitous conserved processes that repair DNA damage are essential for the maintenance and propagat...
Single-molecule approaches permit an unrivalled view of how complex systems operate and have recentl...
Advances in single-molecule techniques have uncovered numerous biological secrets that cannot be dis...
Single-molecule approaches permit an unrivalled view of how complex systems operate and have recentl...
DNA is under constant threat of damage from a variety of chemical and physical insults, such as ultr...
AbstractDNA repair safeguards the genome against a diversity of DNA damaging agents. Although the me...
Single-molecule approaches to solving biophysical problems are powerful tools that allow static and ...
DNA repair safeguards the genome against a diversity of DNA damaging agents. Although the mechanisms...
The study of biomolecules on a single molecule level enables the investigations of dynamic, mechanis...
DNA mismatch repair involves is a widely conserved set of proteins that is essential to limit geneti...
Biological systems create designs that respond to the need to perform specific functions. In particu...
The cellular genetic information is encoded in double-stranded DNA. The separation of DNA strands in...
To combat the destructive effects of damage to DNA, different repair mechanisms play central roles. ...
Numerous agents of endogenous and exogenous origin damage DNA in our genome. There are several DNA-r...
A powerful new approach has become much more widespread and offers insights into aspects of DNA repa...
Ubiquitous conserved processes that repair DNA damage are essential for the maintenance and propagat...
Single-molecule approaches permit an unrivalled view of how complex systems operate and have recentl...
Advances in single-molecule techniques have uncovered numerous biological secrets that cannot be dis...
Single-molecule approaches permit an unrivalled view of how complex systems operate and have recentl...
DNA is under constant threat of damage from a variety of chemical and physical insults, such as ultr...
AbstractDNA repair safeguards the genome against a diversity of DNA damaging agents. Although the me...
Single-molecule approaches to solving biophysical problems are powerful tools that allow static and ...
DNA repair safeguards the genome against a diversity of DNA damaging agents. Although the mechanisms...
The study of biomolecules on a single molecule level enables the investigations of dynamic, mechanis...
DNA mismatch repair involves is a widely conserved set of proteins that is essential to limit geneti...
Biological systems create designs that respond to the need to perform specific functions. In particu...
The cellular genetic information is encoded in double-stranded DNA. The separation of DNA strands in...
To combat the destructive effects of damage to DNA, different repair mechanisms play central roles. ...
Numerous agents of endogenous and exogenous origin damage DNA in our genome. There are several DNA-r...