RATIONALE: Monoaminergic imbalances play a role in the pathogenesis of depression and most common antidepressant drugs act on monoamine neurotransmitters. However, the lag time between restoring neurochemical balance and symptom improvement suggests that the response to drugs involves complex biological events downstream of primary targets that have not yet been fully characterized. Here, we report a mouse mRNA expression study to evaluate the effect of escitalopram (a serotonergic antidepressant) and nortriptyline (a noradrenergic antidepressant) on genes that are involved in the pathogenesis of depression and to assess the similarities and differences between two drugs on gene expression levels. METHODS: Genome-wide RNA expression data fr...
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 enc...
Currently, the biological bases of depression and the molecular mechanisms underlying antidepressant...
National audienceMajor depressive disorder (MDD) is a leading cause of disability worldwide and alte...
BackgroundAntidepressant drugs are used as first-line treatment in depression, but response has been...
Background Antidepressant drugs are used as first-line treatment in depression, but response has bee...
Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized...
Antidepressants arc widely used for the treatment of psychiatric disorders, including depression and...
Antidepressant-induced hippocampal neurogenesis (AHN) is hypothesized to contribute to increases in ...
In this study, we present a pharmacoproteomic investigation of response to antidepressants two inbre...
Adult hippocampal neurogenesis has been implicated in the pathophysiology of depression and in the t...
Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized...
Antidepressants arc widely used for the treatment of psychiatric disorders, including depression and...
The mechanisms by which antidepressants have their effects are not clear and the reasons for variabi...
Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currentl...
Antidepressants (ADs) are, for now, the best everyday treatment we have for moderate to severe major...
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 enc...
Currently, the biological bases of depression and the molecular mechanisms underlying antidepressant...
National audienceMajor depressive disorder (MDD) is a leading cause of disability worldwide and alte...
BackgroundAntidepressant drugs are used as first-line treatment in depression, but response has been...
Background Antidepressant drugs are used as first-line treatment in depression, but response has bee...
Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized...
Antidepressants arc widely used for the treatment of psychiatric disorders, including depression and...
Antidepressant-induced hippocampal neurogenesis (AHN) is hypothesized to contribute to increases in ...
In this study, we present a pharmacoproteomic investigation of response to antidepressants two inbre...
Adult hippocampal neurogenesis has been implicated in the pathophysiology of depression and in the t...
Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized...
Antidepressants arc widely used for the treatment of psychiatric disorders, including depression and...
The mechanisms by which antidepressants have their effects are not clear and the reasons for variabi...
Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currentl...
Antidepressants (ADs) are, for now, the best everyday treatment we have for moderate to severe major...
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 enc...
Currently, the biological bases of depression and the molecular mechanisms underlying antidepressant...
National audienceMajor depressive disorder (MDD) is a leading cause of disability worldwide and alte...