A series of novel 8-aminophenoxazin-3-one and 7-aminophenoxazin-3-one chromogens and their corresponding β-alanine derivatives were synthesized and evaluated for their ability to detect β-alanyl aminopeptidase activity in bacteria known to hydrolyse β-alanine derivatized substrates. The results provided insight into the structural requirements for effective visualization of enzymatic activity and the mechanism of formation of phenoxazinon-3-ones. 8-Aminophenoxazin-3-one substrates 23c, 23d and 23e were prepared in good to high overall yield and were selective for β-alanyl aminopeptidase activity in bacteria, producing a lighter agar background coloration facilitating visualization of colored colonies, with variable localization to the colon...
In clinical diagnostics, the speed and accuracy with which pathogenic microorganisms may be detected...
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious illness, especially in immun...
Three potential chromogenic enzymatic probes, each possessing a self-immolative spacer unit, were sy...
A series of novel 8-aminophenoxazin-3-one and 7-aminophenoxazin-3-one chromogens and their correspon...
The present work investigated the preparation of phenoxazinone derivatives and evaluated their perf...
In clinical microbiology the speed with which pathogenic microorganisms may be detected has a direct...
Pseudomonas aeruginosa is a Gram-negative pathogenic bacteria and a common cause of nosocomial infec...
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacteria and a primary cause of nosocomial infe...
\ua9 2014 Elsevier Ltd. All rights reserved. A series of amino acid derivatives 8-10, 42 and 43 have...
Many diseases are caused by pathogenic bacteria. A key example of this is sepsis, which is mostly ca...
Pseudomonas aeruginosa is a pathogenic bacterium that infects many hospitalized patients with compro...
Pseudomonas aeruginosa produces a number of proteases that are associated with virulence and disease...
Pseudomonas aeruginosa est une bactérie à Gram négatif ayant un rôle central dans la morbidité et la...
AbstractNew fluorogenic enzyme substrates were synthesized by the coupling of aminonaphthalenesulfon...
The synthesis and microbiological evaluation of 7-, 8- and 9-nitro-1,2,4-trihalogenophenoxazin-3-one...
In clinical diagnostics, the speed and accuracy with which pathogenic microorganisms may be detected...
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious illness, especially in immun...
Three potential chromogenic enzymatic probes, each possessing a self-immolative spacer unit, were sy...
A series of novel 8-aminophenoxazin-3-one and 7-aminophenoxazin-3-one chromogens and their correspon...
The present work investigated the preparation of phenoxazinone derivatives and evaluated their perf...
In clinical microbiology the speed with which pathogenic microorganisms may be detected has a direct...
Pseudomonas aeruginosa is a Gram-negative pathogenic bacteria and a common cause of nosocomial infec...
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacteria and a primary cause of nosocomial infe...
\ua9 2014 Elsevier Ltd. All rights reserved. A series of amino acid derivatives 8-10, 42 and 43 have...
Many diseases are caused by pathogenic bacteria. A key example of this is sepsis, which is mostly ca...
Pseudomonas aeruginosa is a pathogenic bacterium that infects many hospitalized patients with compro...
Pseudomonas aeruginosa produces a number of proteases that are associated with virulence and disease...
Pseudomonas aeruginosa est une bactérie à Gram négatif ayant un rôle central dans la morbidité et la...
AbstractNew fluorogenic enzyme substrates were synthesized by the coupling of aminonaphthalenesulfon...
The synthesis and microbiological evaluation of 7-, 8- and 9-nitro-1,2,4-trihalogenophenoxazin-3-one...
In clinical diagnostics, the speed and accuracy with which pathogenic microorganisms may be detected...
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious illness, especially in immun...
Three potential chromogenic enzymatic probes, each possessing a self-immolative spacer unit, were sy...