Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial
- Mfinanga, Sayoki
- Chanda, Duncan
- Kivuyo, Sokoine L
- Guinness, Lorna
- Bottomley, Christian
- Simms, Victoria
- Chijoka, Carol
- Masasi, Ayubu
- Kimaro, Godfather
- Ngowi, Bernard
- Kahwa, Amos
- Mwaba, Peter
- Harrison, Thomas S
- Egwaga, Saidi
- Jaffar, Shabbar
- REMSTART trial team
DOIAbstract
BACKGROUND: Mortality in people in Africa with HIV infection starting antiretroviral therapy (ART) is high, particularly in those with advanced disease. We assessed the effect of a short period of community support to supplement clinic-based services combined with serum cryptococcal antigen screening. METHODS: We did an open-label, randomised controlled trial in six urban clinics in Dar es Salaam, Tanzania, and Lusaka, Zambia. From February, 2012, we enrolled eligible individuals with HIV infection (age ≥18 years, CD4 count of <200 cells per μL, ART naive) and randomly assigned them to either the standard clinic-based care supplemented with community support or standard clinic-based care alone, stratified by country and clinic, in pe...
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