Quantitative evaluation of the strategy to eliminate human African trypanosomiasis in the Democratic Republic of Congo
- Rock, Kat S.
- Torr, Steve
- Lumbala, Crispin
- Keeling, Matt J.
DOIAbstract
Background: The virulent vector-borne disease, Gambian human African trypanosomiasis (HAT), is one of several diseases targeted for elimination by the World Health Organization. This article utilises human case data from a high-endemicity region of the Democratic Republic of Congo in conjunction with a suite of novel mechanistic mathematical models to address the effectiveness of on-going active screening and treatment programmes and compute the likely time to elimination as a public health problem (i.e. <1 case per 10,000 per year). Methods: The model variants address uncertainties surrounding transmission of HAT infection including heterogeneous risk of exposure to tsetse bites, non-participation of certain groups during active sc...
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