Reply - Letter to the Editor - Malnutrition: The kiss of grim reaper

Conducting a large, multicenter, prospective, randomized clinical trial poses a number of challenges. In particular, the successful completion of the trial is based on devising a protocol which could yield to clinically relevant answers yet no becoming so complex and sophisticated to prevent centers' participation and patients' enrollment. Consequently, the methodology of any trial reflects the clinical questions it tries to address