Natriuretic peptides and integrated risk assessment for cardiovascular disease. an individual-participant-data meta-analysis
- Peter, Willeit
- Stephen Kaptoge, Paul Welsh
- Adam S, Butterworth
- Rajiv, Chowdhury
- Sarah, A. Spackman
- Lisa, Pennells
- Pei, Gao
- Stephen, Burgess
- Daniel F, Freitag
- Michael, Sweeting
- Angela M, Wood
- Nancy, R. Cook
- Suzanne, Judd
- Stella, Trompet
- Vijay, Nambi
- Michael, Hecht Olsen
- Brendan, M. Everett
- Frank, Kee
- Johan, Ärnlöv
- Veikko, Salomaa
- Daniel, Levy
- Jussi, Kauhanen
- Jari A. Laukkanen, Maryam Kavousi
- Toshiharu, Ninomiya
- Juan Pablo, Casas
- Lori B, Daniels
- Lars, Lind
- Caroline, N. Kistorp
- Jens, Rosenberg
- Thomas, Mueller
- Rubattu, Speranza Donatella
- Demosthenes, B. Panagiotakos
- Oscar, H. Franco
- James A, de Lemos
- Andreas, Luchner
- Jorge R, Kizer
- Stefan, Kiechl
- Jukka, T. Salonen
- Goya Wannamethee, S
- Rudolf, A. de Boer
- Børge G, Nordestgaard
- Jonas, Andersson
- Torben, Jørgensen
- Olle, Melander
- Christie M, Ballantyne
- Christopher, Defilippi
- Paul M, Ridker
- Mary, Cushman
- Wayne, D. Rosamond
- Simon G, Thompson
- Vilmundur, Gudnason
- Naveed, Sattar
- John, Danesh
- DI ANGELANTONIO, Emanuele
DOIAbstract
BACKGROUND: Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. METHODS: In this individual-participant-data meta-analysis, we generated and harmonised individual-participant data from relevant prospective studies via both de-novo NT-proBNP concentration measurement of stored samples and collection of data from studies identified through a systematic search of the literature (PubMed, Scientific Citation Index Expanded, ...
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